A Phase 1 Study Evaluating CPI-0610 in Patients With Progressive Lymphoma
NCT01949883 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 64
Last updated 2024-05-08
Summary
First in human, open-label, sequential dose escalation and expansion study of CPI-0610 in patients with progressive lymphoma. CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins.
Conditions
Interventions
- DRUG
-
CPI-0610
Sponsors & Collaborators
-
The Leukemia and Lymphoma Society
collaborator OTHER -
Constellation Pharmaceuticals
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2013-09-05
- Primary Completion
- 2017-12-20
- Completion
- 2017-12-20
More Related Trials
-
Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor Zanubrutinib
NCT05068440 ·Status: COMPLETED ·Phase: PHASE2
-
Phase Ib Study of Rocbrutinib in Combination with R-CHOP in Patients with Newly Diagnosed B-cell Non-Hodgkin Lymphoma
NCT06251180 ·Status: RECRUITING ·Phase: PHASE1
-
Axicabtagene Ciloleucel:Neurocognitive and Patient-Reported Outcomes
NCT04319237 ·Status: COMPLETED
-
Copanlisib and Gemcitabine in Relapsed/Refractory PTCL
NCT03052933 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma
NCT03778073 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma
NCT01974440 ·Status: COMPLETED ·Phase: PHASE3
-
Mitoxantrone Hydrochloride Liposome and Enlonstobart Combination Treatment in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL)
NCT07288814 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies
NCT04450069 ·Status: COMPLETED ·Phase: PHASE1
-
An Open Label Treatment Use Protocol for Ibrutinib in Subjects With Relapsed or Refractory Mantle Cell Lymphoma
NCT01833039 ·Status: APPROVED_FOR_MARKETING
-
CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
NCT04637763 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Rocbrutinib in Participants With Relapse or Refractory Non-GCB Diffuse Large B-Cell Lymphoma
NCT07189065 ·Status: RECRUITING ·Phase: PHASE2
-
Study of BTK Inhibitor Zanubrutinib in Participants With Relapsed/Refractory Non-GCB Type Diffuse Large B Cell Lymphoma
NCT03145064 ·Status: COMPLETED ·Phase: PHASE2
-
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900 ·Status: RECRUITING ·Phase: PHASE1
-
Combination of PCI-32765 With Obinutuzumab in Untreated Follicular Lymphoma
NCT02689869 ·Status: UNKNOWN ·Phase: PHASE2
-
Pro-miniCHOP-like Regimen for Treatment-naive Elderly Patients
NCT05809180 ·Status: RECRUITING ·Phase: NA
-
Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas
NCT03586999 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Zanubrutinib and Lenalidomide as Maintenance Therapy in DLBCL
NCT06503263 ·Status: RECRUITING ·Phase: PHASE2
-
Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Toripalimab for Patients With Recurrent Malignant Lymphoma
NCT03316144 ·Status: COMPLETED ·Phase: PHASE1
-
Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL)
NCT03581942 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma
NCT05021770 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Zanubrutinib Monotherapy in Relapsed/Refractory Central Nervous System Lymphoma
NCT05117814 ·Status: UNKNOWN ·Phase: NA
-
A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma
NCT01855750 ·Status: COMPLETED ·Phase: PHASE3
-
Phase Ⅰ Clinical Study of Anti-CD52 Monoclonal Antibody in NHL and T-PLL
NCT05557903 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety and Efficacy Study of CNOP Chemotherapy in Diffuse Large B Cell Lymphoma
NCT02595242 ·Status: WITHDRAWN ·Phase: PHASE1
-
Zanubrutinib-based Maintenance Therapy of Newly Diagnosed DLBCL With Initial Remission
NCT06669143 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2