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Bone Loss in Patients With Anorexia Nervosa

NCT01907464 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2026-05-14

No results posted yet for this study

Summary

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.

160 patients (age \< 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Conditions

  • Patients With Anorexia Nervosa

Interventions

OTHER

clinical parameters description

description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms

OTHER

para clinical parameters description

description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms

OTHER

hormonal parameters dosing

dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms

OTHER

bone modeling markers dosing

dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms

Sponsors & Collaborators

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Patrick PL LEFEBVRE, MD · University Hospital, Montpellier

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
38 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2017-04-30
Completion
2017-04-25

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01907464 on ClinicalTrials.gov