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Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence

NCT01904487 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2017-08-29

No results posted yet for this study

Summary

Background:

\- This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system. It helps induce relaxation and sleep and balances the brain by inhibiting over-excitation. Several studies have reported that anxiety disorders such as panic attacks, seizure disorders, and numerous other conditions including addiction, are all related to low GABA activity. Therefore, we will examine differences in GABA levels between healthy controls and subjects with alcohol addiction. Studies such as this are important to the understanding of the role of GABA in alcohol addiction.

Conditions

  • Alcoholism

Interventions

RADIATION

[11C]flumazenil

\[11C\]flumazenil is a radiotracer used to measure levels of the neurotransmitter GABA in the human brain.

DRUG

Tiagabine

Tiagabine raises levels of GABA in the brain. It is used in this study so that we can measure the changes in GABA levels.

Sponsors & Collaborators

  • Rajesh Narendran

    lead OTHER

Principal Investigators

  • Rajesh Narendran, MD · University of Pittsburgh

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-04-19
Primary Completion
2013-10-01
Completion
2013-10-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01904487 on ClinicalTrials.gov