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Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange

NCT01894191 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 651

Last updated 2016-06-28

No results posted yet for this study

Summary

Interval (missed) cancers and lower than expected mortality reduction of proximal colon cancers in the United States and elsewhere after screening colonoscopy drew attention to quality indicators. Missed adenomas which are more likely to be in the proximal colon may be contributing factors. An independent predictor of the risk of interval cancers is adenoma detection rate. In pilot observations, the investigators showed that water exchange enhanced adenoma detection in the right colon (cecum to hepatic flexure). This prospective, randomized controlled trial will compare water exchange with water immersion and traditional air insufflation in patients undergoing colonoscopy. The investigators test the hypothesis that compared with air insufflation and water immersion, water exchange produces a significantly higher adenoma detection rate in the right colon.

Conditions

  • Adenoma

Interventions

PROCEDURE

Air insufflation

Insufflation during colonoscopy including insertion phase

PROCEDURE

water immersion

Water will infused during insertion phase and removed during withdrawal phase of colonoscopy

PROCEDURE

Water exchange

Water will infused and removed during insertion phase of colonoscopy

Sponsors & Collaborators

  • Sepulveda Ambulatory Care Center, VAGLAHS

    collaborator UNKNOWN

  • Dalin Tzu Chi General Hospital

    lead OTHER

Principal Investigators

  • Yu-Hsi Hsieh, MD · Buddhist Dalin Tzu Chi Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • United States
  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01894191 on ClinicalTrials.gov