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Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer

NCT01885754 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2017-01-06

No results posted yet for this study

Summary

Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown.

Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis.

Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days.

During the evaluation the following tests will be done:

* Anthropometric measures
* Level of daily physical activity
* Pulmonary function test
* Maximal incremental cardiopulmonary exercise test on ergocycle
* Endurance test on ergocycle
* Muscle function tests
* Magnetic stimulation
* Quadriceps biopsy

Conditions

  • Non-Small-cell Lung Cancer

Sponsors & Collaborators

  • Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec

    lead OTHER

Principal Investigators

  • Didier Saey, PhD · Institut universitaire de cardiologie et de pneumologie de Québec, University Laval

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2017-07-31
Completion
2017-10-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01885754 on ClinicalTrials.gov