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Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease

NCT01871779 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2013-06-07

No results posted yet for this study

Summary

Cardiovascular disease remain one of the leading causes of death in Australia, accounting for 47637 (36%) of deaths in 2004.

Peripheral arterial disease (PAD) is a category of cardiovascular disease, characterised by intermittent claudication. This is defined as walking induced pain, cramping, aching, tiredness or heaviness in one or both legs that does not go away with continued walking and is relieved with rest. It is estimated that between 5-10% of individuals aged over 50 years suffer from claudication. The primary and most effective treatment for these patients is focused on improving walking ability and functional status.

Current research has shown that approximately 30% of patients improve with exercise, while 30% continue to deteriorate and the rest show no change. The changes produced at a biochemical and cellular level due to exercise are unknown. To help better understand this, our study will assess the entire range of proteins expressed before and after exercise in the skeletal muscle tissue of patients with intermittent claudication. This will help to identifying key proteins that have a role in improving patient symptoms and outcome.

Conditions

  • Peripheral Arterial Disease

Interventions

OTHER

Standard Treadmill Exercise

Standard treadmill exercise to the point of pain twice weekly for 35-45 minutes for 12 weeks

OTHER

Intermittent treadmill & resistance training

Combination of standard treadmill training and resistance training with weights twice weekly for 12 weeks

Sponsors & Collaborators

  • Flinders Medical Centre

    collaborator OTHER_GOV

  • Royal Adelaide Hospital

    collaborator OTHER

  • The Queen Elizabeth Hospital

    collaborator OTHER

  • Flinders University

    lead OTHER

Principal Investigators

  • Christopher L Delaney, BMBS · Flinders University and Flinders Medical Centre Department of Vascular Surgery

  • James I Spark, MBChB, MD, · Flinders University and Flinders Medical Centre Department of Vascular Surgery

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2012-12-31
Completion
2013-02-28

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01871779 on ClinicalTrials.gov