Trial Outcomes & Findings for Toronto Thromboprophylaxis Patient Safety Initiative (NCT NCT01869075)

Last Updated: 2014-09-23

Results Overview

Rates of appropriate VTE prophylaxis were determined as the number of patients who received VTE prophylaxis as a proportion of the number of patient at risk. Rates reported are for the active phases (phase 1 and phase 2) and compare intervention to control. Appropriate VTE prophylaxis was defined as: in "Hip Fracture Surgery" - evidence-based VTE prophylaxis ordered within 24 of admission, restarted within 24 hours after surgery and continued for at least 10 days post-discharge in "Major General Surgery" - evidence-based VTE prophylaxis ordered within 24 hours post-surgery and continued for the duration of hospital stay in "Acute Medical Illness" - evidence-based VTE prophylaxis ordered within 24 hours of admission and continued for the duration of hospital stay. Evidence-based VTE prophylaxis was determined to be according to the American College of Chest Physicians (ACCP) guidelines. The 9th version was the most current version at the time of the study.

Recruitment status

COMPLETED

Study phase

Target enrollment

1895 participants

Primary outcome timeframe

End of study (end of phase 2) - measured over duration of hospital stay.

Results posted on

2014-09-23

Participant Flow

Recruitment of study sites not individual patients.

After site enrolment, baseline data was collected for all sites in order to establish sample size for phases 1 and 2.

Participant milestones

Participant milestones
Measure	AMI - Knowledge Translation Toolkit AMI - Knowledge Translation (KT) toolkit includes use of pre-printed orders, audit and feedback, pharmacist as a reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	AMI - Usual Care Usual care provided at the hospital	MGS - Knowledge Translation Toolkit Knowledge Translation toolkit involves use of pre-printed orders, audit and feedback, pharmacist as reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	MGS - Usual Care Usual care provided at the hospital	HFS - Knowledge Translation Toolkit Knowledge Translation Toolkit consists of pre-printed orders, audit and feedback, pharmacist as a reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	HFS - Usual Care Usual care provided at the hospital
Phase 0 (Baseline) STARTED	0	418	0	416	0	341
Phase 0 (Baseline) COMPLETED	0	418	0	416	0	341
Phase 0 (Baseline) NOT COMPLETED	0	0	0	0	0	0
Phase 1 STARTED	45	75	45	75	30	90
Phase 1 COMPLETED	45	75	45	75	30	90
Phase 1 NOT COMPLETED	0	0	0	0	0	0
Phase 2 STARTED	90	30	75	45	75	45
Phase 2 COMPLETED	90	30	75	45	75	45
Phase 2 NOT COMPLETED	0	0	0	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Toronto Thromboprophylaxis Patient Safety Initiative

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	AMI - Knowledge Translation Toolkit AMI - Knowledge Translation (KT) toolkit includes use of pre-printed orders, audit and feedback, pharmacist as a reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	AMI - Usual Care n=341 Participants Usual care as provided at the hospital.	MGS - Knowledge Translation Toolkit Knowledge Translation toolkit involves use of pre-printed orders, audit and feedback, pharmacist as reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	MGS - Usual Care n=416 Participants Usual Care as provided at the hospital.	HFS - Knowledge Translation Toolkit Knowledge Translation Toolkit consists of pre-printed orders, audit and feedback, pharmacist as a reminder and education of staff Knowledge Translation (KT) toolkit: KT toolkit consists of: use of pre-printed orders, use of pharmacist as project lead and human reminder for prescribing, audit and feedback, education for staff	HFS - Usual Care n=418 Participants Usual Care as provided at the hospital.	Total n=1175 Participants Total of all reporting groups
Age, Customized 18 years and older	—	341 participants n=107 Participants	—	416 participants n=7 Participants	—	418 participants n=30 Participants	1175 participants n=3 Participants
Sex: Female, Male Female	—	NA Participants n=107 Participants	—	NA Participants n=7 Participants	—	NA Participants n=30 Participants	NA Participants n=3 Participants
Sex: Female, Male Male	—	NA Participants n=107 Participants	—	NA Participants n=7 Participants	—	NA Participants n=30 Participants	NA Participants n=3 Participants

PRIMARY outcome

Timeframe: End of study (end of phase 2) - measured over duration of hospital stay.

Population: The number of participants in the analysis was 720. In phase 1, there were 360 patients included and in phase 2, an additional 360 patients were included. The outcomes by end of study (end of phase 2) are reported. The patients in control (usual care) and intervention (Knowledge Translation toolkit) were compared.