Modafinil for Smoked Cocaine Self-Administration

Summary

Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administration by frequent users (4 days/week) under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of modafinil maintenance (0, 200, and 400mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were examined in nontreatment seeking cocaine-dependent individuals (n = 8).

Conditions

• Cocaine Dependence

Interventions

DRUG

Modafinil 0 mg

Modafinil (0 mg/day)

DRUG

Modafinil 200 mg

Modafinil (200 mg/day)

DRUG

Modafinil 400 mg

Modafinil (400 mg/day)

DRUG

Cocaine 0 mg

Cocaine (0 mg/day)

DRUG

Cocaine 12 mg

Cocaine (12 mg/day)

DRUG

Cocaine 25 mg

Cocaine (25 mg/day)

DRUG

Cocaine 50 mg

Cocaine (50 mg/day)

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• New York State Psychiatric Institute

  lead OTHER

Principal Investigators

• Margaret Haney, Ph.D. · NYS Psychiatric Institute

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

21 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-03-31

Primary Completion

2013-03-31

Completion

2013-06-30

Countries

• United States

Study Locations