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Bacteriology and Inflammation in Bronchiectasis

NCT01761214 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2020-02-11

No results posted yet for this study

Summary

Bronchiectasis is a chronic disease arises from progressive airway inflammation and infection. It has been postulated that bacterial infection triggers intense airway inflammation leading to acute exacerbation of bronchiectasis. Antibiotics have been the most potent medications for the treatment of bronchiectasis, however, the sputum bacterial load and inflammatory indices at steady-state and exacerbation remain largely unknown. The investigation might shed light on the roles that antibiotics play in acute exacerbation of bronchiectasis and uncover the mechanisms on why a subgroup of individuals do not respond satisfactorily.

Conditions

Interventions

DRUG

Fluroquinolones

All antibiotics are administered based on British Thoracic Society guideline for bronchiectasis

DRUG

Beta-lactamase inhibitor

All antibiotics are administered based on British Thoracic Society guideline for bronchiectasis.

Sponsors & Collaborators

  • Guangzhou Institute of Respiratory Disease

    lead OTHER

Principal Investigators

  • Nan-shan Zhong, M. D. · Sate Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College

  • Rong-chang Chen, M. D. · Sate Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01761214 on ClinicalTrials.gov