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Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome

NCT01760668 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2016-05-24

No results posted yet for this study

Summary

The study aim is:

1. To examine aortic tissue by light microscopy
2. To examine aortic tissue by electron microscopy
3. To study changes in the epigenome and transcriptome of the X chromosome specific to aortic tissue.
4. To examine aortic tissue using biochemistry including proteomics.
5. To establish the karyotype of fibroblasts with standard chromosome examination on 10 meta-phases as well as by fluorescent in situ hybridization (FISH) with probes covering the X and Y chromosome. Using the latter 200 meta-phases will be examined.

30 controls who did not die from aortic dissection or dilation will be recruited from The Department of Forensic Medicine at Aarhus University Hospital.

The investigators will subject samples of aortic tissue from women undergoing prophylactic aortic surgery due to either Marfan syndrome or bicuspid aortic valve to the same panel of examinations (except karyotyping). Lastly the investigators will compare the results from the three groups (Turner syndrome, Marfan syndrome and Bicuspid aortic valve).

Conditions

  • Turner Syndrome
  • Bicuspid Aortic Valve
  • Marfan Syndrome

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Christian Trolle · Aarhus University Hospital

  • Claus H Gravholt, MD, Ph.d. · Aarhus University Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2015-10-31
Completion
2015-10-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01760668 on ClinicalTrials.gov