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Total Occlusion Study in Coronary Arteries - 5

NCT01753180 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2016-07-11

No results posted yet for this study

Summary

A prospective, multi-center, double blind, 2 stage, placebo-controlled, phase II study, evaluating acute intra-coronary injected collagenase prior to routine standard-of-care percutaneous revascularization procedures in subjects with chronic total coronary artery occlusions (CTOs).

Conditions

  • Chronic Coronary Total Occlusions

Interventions

BIOLOGICAL

collagenase

Local intra-coronary administration of MZ-004 at or into the CTO

DRUG

saline

Local intra-coronary administration of saline at or into the CTO

Sponsors & Collaborators

  • Matrizyme Pharma Corporation

    lead INDUSTRY

Principal Investigators

  • Christopher Buller, Dr. · St. Michael's Hospital, Toronto, Ontario, Canada

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2015-12-31
Completion
2016-07-31

Countries

  • Canada
  • Israel
  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01753180 on ClinicalTrials.gov