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Management of the Idiopathic Overactive Bladder With Botulinum Toxin: Systematic Review

NCT01750645 · Status: UNKNOWN · Type: OBSERVATIONAL

Last updated 2012-12-17

No results posted yet for this study

Summary

Overactive bladder is defined as a syndrome composed of urgency, increased urinary frequency, and sometimes urinary incontinence; its etiology may be characterized as neurogenic or non-neurogenic (i.e., idiopathic). This illness has a great impact in quality of life and one of the available treatments is the injection of Botulinum Toxin. This study aims to review the efficacy and safety of type-A Botulinum Toxin in the management of Idiopathic Overactive Bladder. A systematic search was performed in MEDLINE, EMBASE, CENTRAL and LILACS, and the controlled randomized clinical trials were chosen to review with the CONSORT criteria by independent reviewers. Outcomes analyzed were the efficacy of the intervention for relieving the symptoms (urgency, frequency and urgency incontinence), adverse events to treatment, change in quality of life and urodynamic measures.

Conditions

  • Urinary Bladder, Overactive

Interventions

DRUG

Intradetrusor Injection of Type-A Botulinum Toxin

OTHER

Other interventions analyzed according to protocol

* Placebo * Different dosage of Type-A Botulinum Toxin injected * Anticholinergic drugs

Sponsors & Collaborators

  • Clínica Infantil Colsubsidio

    lead OTHER

Principal Investigators

  • Hugo E López, MD · Clínica Infantil Colsubsidio

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-07-31
Primary Completion
2012-10-31
Completion
2013-01-31

Countries

  • Colombia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01750645 on ClinicalTrials.gov