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Effects of Chemotherapy on Muscle Mass and Exercise Performance in Patients With Oesophageal Cancer.

NCT01742312 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2016-02-18

No results posted yet for this study

Summary

Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.

Conditions

  • Oesophageal Adenocarcinoma

Interventions

RADIATION

DEXA scan

all patients will undertake a full body DEXA scan before and after chemotherapy

PROCEDURE

Muscle biopsy

All patients will have a muscle biopsy before and after chemotherapy

OTHER

cardio-pulmonary exercise testing (CPEX)

patients will undertake exercise in the form of an exercise bike whilst having their cardiac and ventilatory performance analysed. This will take place before and after neoadjuvant chemotherapy

Sponsors & Collaborators

  • University Hospitals of Derby and Burton NHS Foundation Trust

    collaborator OTHER

  • University of Nottingham

    lead OTHER

Principal Investigators

  • John Williams, MBChB, FFPMRCA, PhD · Graduate Entry Medical School, University of Nottingham

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-10-31
Primary Completion
2013-01-31
Completion
2013-01-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01742312 on ClinicalTrials.gov