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Pathophysiology of Central Apnoeas in Stroke Patients

NCT01723189 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2012-11-07

No results posted yet for this study

Summary

40% of patients with Sleep Disorder Breathing (SDB) appearing during the acute phase of stroke show a respiratory pattern characterized by central apnoeas and/or periodic breathing.

Clinical studies conducted in patients with hearth failure and central apnoeas have demonstrated the pathogenetic central role of hypersensitivity of central and peripheral chemoreceptors in association with baroreflex hypersensitivity, expression of hyperactivity of sympathetic nervous system.

The joint study of chemoreflexes and baroreflexes in patients with central apneas during the acute and subacute phase of ischemic stroke represents, to our knowledge, a novelty in literature, that should supply useful elements to clarify the pathogenesis and the clinical and prognostic significance of these disorders.

Investigators expect a difference in the analysis of the baroreflexes and chemoreflexes in patients with ischemic stroke/transient ischemic attack (TIA) and central apnoeas than patients with ischemic stroke not accompanied by respiratory problems and compared with healthy controls.

Conditions

  • Central Apnoeas
  • Stroke Patients

Sponsors & Collaborators

  • Advisory Board of scientific Reserch Ente Ospedaliero Cantonale, ABREOC

    collaborator UNKNOWN

  • University of Geneva, Switzerland

    collaborator OTHER

  • University of Milan

    collaborator OTHER

  • MPons

    lead OTHER_GOV

Principal Investigators

  • Marco Pons, MD · Ospedale Regionale di Lugano - Civico

Eligibility

Min Age
35 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2014-08-31
Completion
2014-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01723189 on ClinicalTrials.gov