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Effect of Body Mass on Acyclovir Pharmacokinetics

NCT01714180 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2015-06-03

No results posted yet for this study

Summary

Studies have shown that different percentages of body fat can alter the way drugs are distributed in the body. This study will use blood samples taken at different time points for patients taking acyclovir to determine if higher body weights affect drug exposure. The information gathered from this study will help understand if patients with higher body weights need a different dosing plan.

Patients receiving acyclovir as standard of care will be enrolled into this study. They will have blood draws once before they take acyclovir and 10 times after they take the acyclovir (over a total of 12 hours). These patients will be in the hospital already and will not need to make additional trips back to have blood drawn. A total of about 4-5 tablespoons of blood will be drawn for this study. 7 obese patients and 7 matched, non-obese patients will be enrolled into this study.

Conditions

  • Hematological Malignancy
  • Pharmacokinetics of Acyclovir

Sponsors & Collaborators

  • West Virginia University

    lead OTHER

Principal Investigators

  • Aaron Cumpston, PharmD · West Virginia University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2014-03-31
Completion
2015-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01714180 on ClinicalTrials.gov