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Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty

NCT01707953 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2014-01-20

No results posted yet for this study

Summary

The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.

Conditions

  • Postoperative Orthostatic Hypotension
  • Postoperative Orthostatic Intolerance

Interventions

DRUG

Midodrine

Midodrine 5mg as capsule, administered twice (5 and 23 hours after end of surgery).

DRUG

Placebo

Placebo capsule to mimic midodrine

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Henrik Kehlet, Proffessor · Rigshospitalet, Section for Surgical Pathophysiology

  • Oeivind Jans, M.D. · Rigshospitalet, Section for Surgical Pathophysiology

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01707953 on ClinicalTrials.gov