MedTrace Logo

Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation

NCT01703806 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1063

Last updated 2025-01-29

No results posted yet for this study

Summary

The timing of surgical intervention in asymptomatic patients with severe degenerative mitral regurgitation (MR) remains controversial. The benefit of early surgery has been suggested in prospective, observational studies, whereas a watchful waiting strategy seemed to be safe and effective in the other prospective study. The consensus guidelines for the performance of early surgery in asymptomatic patients with severe MR are different, reflecting controversy. Clinical outcome in asymptomatic patients with MR is poorly defined and it is important to identify high-risk patients in whom early surgery may be warranted. Thus, the investigators try to compare long-term outcomes of early surgery with those of a conventional-treatment strategy in a large prospective cohort of asymptomatic patients with severe degenerative MR using a propensity analysis, and to identify high-risk subgroups to whom early surgery is more beneficial.

Conditions

  • Mitral Regurgitation

Interventions

PROCEDURE

Early Surgery

MItral valve surgery

PROCEDURE

Watchful Observation

Watchful observation

Sponsors & Collaborators

  • Asan Medical Center

    lead OTHER

Principal Investigators

  • Duk-Hyun Kang, MD, PhD · Asan Medical Center

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1996-07-31
Primary Completion
2024-10-31
Completion
2024-10-31

Countries

  • South Korea

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01703806 on ClinicalTrials.gov