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Intraoperative Anuric Episodes in Patients Undergoing Laparotomy

NCT01703442 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2016-08-11

No results posted yet for this study

Summary

A single-center prospective observational study. This study examines urine flow and haemodynamic parameters during abdominal surgery and analyses the association to postoperative renal function and markers and to postoperative clinical outcome.

Primary hypothesis:

• Within a goal-directed haemodynamic protocol during gynecologic cancer surgery there are phases of temporary anuria.

Secondary hypothesis:

* Perioperative anuric phases are directly associated to the postoperative increase of NGAL (neutrophil gelatinase-associated lipocalin) and creatinine
* Perioperative renal dysfunction is directly associated to postoperative complications and functional recovery of patients
* A response of urine flow to a standardized postoperative diuretic bolus can identify patients who benefit from a pharmaceutical fluid mobilization
* Within a goal-directed haemodynamic protocol during gynaecologic cancer surgery, the methods for the measurement of stroke volume of the heart differ

Conditions

  • Intraoperative Anuria

Sponsors & Collaborators

  • Claudia Spies

    lead OTHER

Principal Investigators

  • Claudia Spies, MD, Prof. · Department of Anesthesiology and Intensive Care Medicine CVK/CCM, Charité - University Berlin

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2018-06-30
Completion
2018-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01703442 on ClinicalTrials.gov