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Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis

NCT01670305 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2013-09-12

No results posted yet for this study

Summary

Residual pockets and furcation defects are challenging sites that require additional periodontal therapy. The aim of this study is evaluate 1)the effect of a single photodynamic therapy (PDT) as monotherapy residual pockets in single rooted teeth and 2) the effect of PDT in association with scaling and root planing (SRP) in class II furcation lesions with probing pocket depth (PPD) \>5mm and bleeding on probing (BoP). A blind randomized controlled clinical trial was conducted in subjects presenting at least three residual pockets in single root teeth and subjects with at least one molar presenting class II furcation defect. To evaluate the effect of a single PDT as monotherapy in residual pockets, the selected sites were assigned to receive: PDT alone, photosensitizer alone or SRP alone. To evaluate the effect of PDT in association with SRP in class II furcation lesions, the selected sites were assigned to PDT+SRP or SRP alone. Clinical, microbiological and immunoenzymatic analyses were assessed at baseline, 3 and 6 months post-therapies.

Conditions

  • Periodontal Disease

Interventions

PROCEDURE

Residual pockets will be treated by laser + photosensitizer

Experimental group: Residual pockets will be treated by laser + photosensitizer

PROCEDURE

Residual pockets will be treated only photosensitizer

Placebo Comparator: Residual pockets will be treated only photosensitizer

PROCEDURE

Residual pockets will be treated scaling and root planing

Active Comparator: Residual pockets will be treated scaling and root planing

PROCEDURE

laser + photosensitizer associated with scaling and root planing

Experimental group: furcation defects will be treated by laser + photosensitizer associated with scaling and root planing

PROCEDURE

furcation defects will be treated by scaling and root planing

Active Comparator: furcation defects will be treated by scaling and root planing

Sponsors & Collaborators

  • Paulista University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-02-28
Primary Completion
2011-05-31
Completion
2013-03-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01670305 on ClinicalTrials.gov