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Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography

NCT01605669 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2016-09-23

Study results available
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Summary

According to the 2006 ACC/AHA practice guidelines for valvular heart disease, patients with asymptomatic aortic stenosis(AS) should have screening transthoracic echocardiograms (TTE) performed annually for severe disease, every 1-2 years for moderate disease and every 3-5 years for mild disease. This results in a multitude of screening studies in the investigators patient population. 3M has developed a new stethoscope and phonocardiography software capable of identifying the peak intensity of the AS murmur and tracking it as it moves towards the second heart sound potentially indicating increasing severity of disease. Currently there exists no data to demonstrate that the aortic stenosis acceleration index (ASAI) correlates to disease severity or progression of disease. The ASAI measures the timing of the peak intensity of the systolic murmur and compares it to the total time in systole (S2-x/s2-s1) where s1 is the first heart sound; S2 is the second heart sound and x with the time between S1 and the peak intensity of the murmur. In this study the investigators propose to correlate the ASAI to standard TTE measurements of aortic stenosis severity.

Conditions

  • Aortic Stenosis

Interventions

OTHER

Tranthoracic Echocardiogram

standard measurement

DEVICE

Cardiac Ascultation Recordings with Electronic stethoscope

3M device

Sponsors & Collaborators

  • 3M

    collaborator INDUSTRY

  • The Geneva Foundation

    collaborator OTHER

  • United States Naval Medical Center, San Diego

    lead FED

Principal Investigators

  • William E Bennett, MD · United States Naval Medical Center, San Diego

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-05-31
Primary Completion
2013-06-30
Completion
2013-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01605669 on ClinicalTrials.gov