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CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery

NCT01587196 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2024-10-15

Study results available
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Summary

The proposed project will use fMRI and specific probes of reward and inhibition as biomarkers predicting drug use during and after treatment in 72 subjects addicted to prescription opioids/medications. Subjects will be scanned before, during, and after 12 weeks of active medication. The brain fMRI measures will be correlated with the primary clinical outcome of drug use (by urine drug screen) during the treatment and follow-up phase.

Conditions

  • Prescription Opiate/Medication Dependence

Interventions

DRUG

Vivitrol

There are monthly injections of depot naltrexone for 3 months.

Sponsors & Collaborators

Principal Investigators

  • Daniel Langleben, MD · Co-Investigator

  • Anna R Childress, MD · Principal Investigator

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2021-01-01
Completion
2021-01-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01587196 on ClinicalTrials.gov