Intensified Secondary Prevention Intending a Reduction of Recurrent Events in TIA and Minor Stroke Patients

Summary

Patients after TIA or Stroke are at high risk of experiencing a new stroke or myocardial infarction. Poor adherence to evidence based secondary prevention regimens is frequently seen. Support programs for patients may not only improve adherence to recommended therapies but also reduce the recurrence rate of stroke and heart attack. The investigators hypothesize that compared to regular care, a structured and patient centered secondary prevention program will lead to a relative risk reduction of at least 28% of recurrent vascular events.

Conditions

• Mini-Stroke

Interventions

BEHAVIORAL

Patient centered structured support program

Behavioural: Structured support program Program with up to 8 outpatient appointments focusing on: * Measurement of risk factors * Assessment of medication intake * Monitoring of antithrombotic therapy * Joint agreement of an individual target plan Target values for risk factors: * Blood pressure \< 140/85 mmHg (\<130/80 in diabetics), normal circadian profile * HbA1c \<7.5% * Nicotine abstinence * LDL \< 100mg/dl (\< 70mg/dl in high risk patients) * Physical activity ≥ 30min \>2 x / week Targets for pharmaceutical treatment: * Platelet inhibitors for strokes / TIA of arterial etiology * Combined platelet inhibition over 3 months in symptomatic intra- or extracranial stenosis * Cumarins (INR 2-3) or new oral anticoagulants in AF patients * Statin treatment in patients with LDL \>100mg/dl Intervention strategies: • According to Motivational Interviewing

Sponsors & Collaborators

• Technical University of Munich

  collaborator OTHER

• University of Erlangen-Nürnberg Medical School

  collaborator OTHER

• Praxis für Neurologie und Psychiatrie am Prinzregentenplatz, München

  collaborator UNKNOWN

• Technische Universität Berlin

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Klinikum Ludwigshafen

  collaborator OTHER

• Vivantes Auguste-Viktoria-Klinikum

  collaborator UNKNOWN

• Vivantes Clinic Neukölln

  collaborator OTHER

• Charite University, Berlin, Germany

  lead OTHER

Principal Investigators

• Heinrich J Audebert, MD · Center for Stroke Research, Charité Universitaetsmedizin Berlin

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-09-30

Primary Completion

2018-12-31

Completion

2019-05-31

Countries

• Germany

Study Locations