Olaparib in Adults With Recurrent/Metastatic Ewing's Sarcoma
NCT01583543 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2017-05-19
Summary
This research study is a Phase II clinical trial to test the efficacy of Olaparib in adult participants with recurrent/metastatic Ewing's Sarcoma following failure of prior chemotherapy.
Conditions
- Ewing's Sarcoma
Interventions
- DRUG
-
400mg PO BID Continuous
Sponsors & Collaborators
-
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Edwin Choy, MD PhD · Massachusetts General Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-05-31
- Primary Completion
- 2014-01-31
- Completion
- 2014-11-30
Countries
- United States
Study Locations
More Related Trials
-
Dinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma
NCT02484443 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma
NCT00003101 ·Status: COMPLETED ·Phase: PHASE2
-
BMS-247550 in Treating Patients With Advanced Soft Tissue Sarcoma
NCT00022542 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase I Study to Examine the Toxicity of Allogeneic Stem Cell Transplantation for Relapsed or Therapy Refractory Ewing Sarcoma
NCT01969942 ·Status: WITHDRAWN ·Phase: PHASE1
-
Busulfan, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk Ewing's Tumors
NCT00357396 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy, Peripheral Stem Cell Transplantation, and Radiation Therapy in Treating Patients With Ewing's Sarcoma, Peripheral Primitive Neuroectodermal Tumor, or Rhabdomyosarcoma
NCT00003081 ·Status: COMPLETED ·Phase: PHASE1
-
TK216 in Patients With Relapsed or Refractory Ewing Sarcoma
NCT02657005 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma
NCT00003667 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Central Nervous System Lymphoma
NCT00003632 ·Status: COMPLETED ·Phase: PHASE2
-
CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
NCT05440786 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Autologous Peripheral Stem Cell Transplant in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
NCT00345865 ·Status: COMPLETED ·Phase: PHASE2
-
Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
NCT04135092 ·Status: NO_LONGER_AVAILABLE
-
Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma
NCT02306161 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients
NCT04067115 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma
NCT00020943 ·Status: COMPLETED ·Phase: PHASE2
-
Study To Examine Toxicity Of Allogeneic Stem Cell Transplantation For Relapsed Or Therapy Refractory Ewings Sarcoma
NCT02472392 ·Status: COMPLETED ·Phase: PHASE1
-
Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma
NCT06492954 ·Status: RECRUITING ·Phase: PHASE1
-
Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus
NCT00033644 ·Status: TERMINATED ·Phase: PHASE2
-
Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy
NCT01871766 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma
NCT00073983 ·Status: COMPLETED ·Phase: PHASE2
-
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer
NCT00729586 ·Status: COMPLETED ·Phase: PHASE2
-
RAD001(Everolimus) in Treating Patients With Myelodysplastic Syndromes
NCT00809185 ·Status: TERMINATED ·Phase: PHASE2
-
Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
NCT00014508 ·Status: COMPLETED ·Phase: PHASE2
-
Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell Lung, Breast, Testicular, or Kidney Cancer That is Metastatic or That Cannot Be Treated With Surgery
NCT00006126 ·Status: WITHDRAWN ·Phase: PHASE1
-
Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma
NCT00004066 ·Status: COMPLETED ·Phase: PHASE2