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Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study

NCT01571908 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 280

Last updated 2015-07-20

No results posted yet for this study

Summary

Magnesium accelerates the reaction of rocuronium, a neuromuscular blocker used for muscle relaxation to ease the intubation during anaesthesia.

Succinylcholine is a very fast reacting neuromuscular blocker. It is often used in emergency procedures, when rapid intubation is necessary.

We want to now if a perfusion of magnesium before anaesthesia accelerates to such an extent the reaction of rocuronium that intubation conditions are comparable or even better than with succinylcholine alone (prior perfusion of saline=placebo)

Conditions

  • Intubation Conditions

Interventions

DRUG

Magnesium perfusion

The patient receives during 15 minutes a perfusion of 60mg/kg of Magnesium sulphate before induction of anaesthesia.

DRUG

Rocuronium

Immediately after anaesthesia induction and loss of consciousness 0,6 mg/kg of rocuronium will be injected

DRUG

Placebo perfusion

The patient receives during 15 minutes a perfusion of 1 ml/kg of saline before induction of anaesthesia

DRUG

Succinylcholine

Immediately after anaesthesia induction at loss of consciousness 1 mg/kg of succinylcholine will be injected

Sponsors & Collaborators

  • University of Lausanne Hospitals

    collaborator OTHER

  • University Hospital, Geneva

    lead OTHER

Principal Investigators

  • Christoph Czarnetzki, MD, PD · University hospitals of Geneva

  • Martin R Tramèr, MD, PhD · University hospitals of Geneva

  • Christian Kern, MD, Prof · University Hospitals of Lausanne, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2015-07-31
Completion
2015-07-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01571908 on ClinicalTrials.gov