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Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology

NCT01563757 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2013-10-29

No results posted yet for this study

Summary

The investigators are studying what causes Plastic Bronchitis and Protein Losing Enteropathy. The investigators think that these problems are from too much of two small proteins called Vasoactive Intestinal Peptide (VIP) and Substance P. VIP and Substance P are important proteins in the body that normally tell the body to make small amounts of fluid and they help the intestines work. Normally, VIP and Substance P are made in the intestines and then destroyed in the lungs after they do their normal work. The investigators think that kids who have Plastic Bronchitis and/or Protein Losing Enteropathy who also had the Fontan surgery might have too much VIP and Substance P in their bodies. The investigators think this causes too much fluid to go in the lungs and too much protein in the intestines.

Conditions

  • Fontan Physiology Patients With PB or PLE
  • Fontan Physiology Patients Without PB or PLE

Sponsors & Collaborators

  • Children's Hospital and Health System Foundation, Wisconsin

    collaborator OTHER

  • Medical College of Wisconsin

    lead OTHER

Principal Investigators

  • Todd Gudausky, MD · Medical College of Wisconsin

  • Jake Scott, MD · Medical College of Wisconsin

  • William Clarke, MD, MS · Medical College of Wisconsin

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01563757 on ClinicalTrials.gov