Clinical Course of Korean Crohn's Disease Cohort

Summary

In the past decade, the incidence and prevalence of CD (Crohn's disease) has continued to increase in Korea. Previous studies have indicated that Asian IBD (inflammatory bowel disease) patients differ from those of Western patients with regard to the genetic susceptibility and some clinical features. However, the available published data from retrospective studies in Korea were largely incomplete. The investigators aim of the study is a set-up of Korean cohort for CD, and thereby to assess the clinical course of Korean CD patients through a prospective multicenter long-term follow-up study. Secondary aims of this study are as follows: (1) to evaluate the efficacy, tolerability, and predictors to response to anti-TNF therapy for CD, (2) to identify the risk factors for postoperative recurrence on the basis of information obtained at initial diagnosis, and (3) to evaluate genotype-phenotype correlation.

Conditions

• Crohn's Disease

Interventions

OTHER

Observation study

No intervention was administered to the participants specifically for the purpose this study. Participant could be on any drug therapy.

Sponsors & Collaborators

• Asan Medical Center

  collaborator OTHER

• Hanyang University

  collaborator OTHER

• Seoul National University

  collaborator OTHER

• Severance Hospital

  collaborator OTHER

• Samsung Medical Center

  collaborator OTHER

• Chung-Ang University Hosptial, Chung-Ang University College of Medicine

  collaborator OTHER

• Kyung Hee University Hospital at Gangdong

  collaborator OTHER

• Kangbuk Samsung Hospital

  collaborator OTHER

• Konyang University Hospital

  collaborator OTHER

• Korea University Anam Hospital

  collaborator OTHER

• Korea University

  collaborator OTHER

• Eulji General Hospital

  collaborator OTHER

• Eulji University

  collaborator OTHER

• SMG-SNU Boramae Medical Center

  collaborator OTHER

• Pusan National University Hospital

  collaborator OTHER

• Inje University

  collaborator OTHER

• Soonchunhyang University Hospital

  collaborator OTHER

• Songdo hospital

  collaborator UNKNOWN

• Yeungnam University Hospital

  collaborator OTHER

• Wonkwang University

  collaborator OTHER

• Wonju Severance Christian Hospital

  collaborator OTHER

• Ewha Womans University

  collaborator OTHER

• Chonnam National University Hospital

  collaborator OTHER

• Jeju National University Hospital

  collaborator OTHER

• Chuncheon Sacred Heart Hospital

  collaborator OTHER

• Hangang Sacred Heart Hospital

  collaborator OTHER

• Dongtan Sacred Heart Hospital

  collaborator OTHER

• Chungbuk National University Hospital

  collaborator OTHER

• The Catholic University of Korea

  collaborator OTHER

• Kyunghee University Medical Center

  lead OTHER

Principal Investigators

• Joo Sung Kim, MD, PhD · Seoul National University Hospital

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-12-31

Primary Completion

2018-12-31

Completion

2019-12-31

Countries

• South Korea

Study Locations