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Tuberculosis Recurrence Upon Treatment With Highly Active Antiretroviral Therapy

NCT01539005 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 402

Last updated 2017-02-02

No results posted yet for this study

Summary

This is a cohort observational study investigating the rate of tuberculosis (TB) recurrence in adult patients who have completed TB therapy for Pulmonary TB (PTB) and are on highly active antiretroviral therapy (HAART).The primary objective of this study is to determine the incidence of TB recurrence in patients on HAART.The study is being conducted at the CAPRISA eThekwini Clinical Research Site (CRS), which is adjacent to the Prince Cyril Zulu Communicable Disease Clinic (PCZCDC), a major urban TB clinic, in Durban, South Africa.No hypotheses will be tested in this study; however, the primary study question will determine the proportion of TB recurrence due to relapse vs. re-infection.The study has enrolled 402 participants

Conditions

Sponsors & Collaborators

  • United States President's Emergency Plan for AIDS Relief

    collaborator FED

  • Howard Hughes Medical Institute

    collaborator OTHER

  • K-RITH

    collaborator OTHER

  • Centre for the AIDS Programme of Research in South Africa

    lead NETWORK

Principal Investigators

  • Kogieleum Naidoo, MBChB · Centre for the AIDS Programme of Research in South Africa

  • Salim S Abdool Karim, MBChB, PhD · Centre for the AIDS Programme of Research in South Africa

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2014-04-23
Completion
2014-04-23

Countries

  • South Africa

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01539005 on ClinicalTrials.gov