Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms
NCT01520220 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 100
Last updated 2017-04-12
Summary
The purpose of this study is to determine a dose of LY2784544 that may be safely administered to participants with myeloproliferative neoplasms.
Conditions
- Myeloproliferative Neoplasms of
- Polycythemia Vera
- Essential Thrombocythemia
- Myelofibrosis
Interventions
- DRUG
-
LY2784544
LY2784544 will be taken by mouth per a specified schedule. Each cycle is 28 days.
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · Eli Lilly and Company
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-06-11
- Primary Completion
- 2015-06-26
- Completion
- 2017-02-24
Countries
- United States
Study Locations
More Related Trials
-
Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia
NCT01772420 ·Status: COMPLETED ·Phase: PHASE2
-
EMD 121974 in Treating Patients With Locally Advanced or Metastatic Cancer
NCT00004258 ·Status: COMPLETED ·Phase: PHASE1
-
Study of LY573636-sodium in Essential Thrombocythemia and Acute Myeloid Leukemia
NCT00718159 ·Status: COMPLETED ·Phase: PHASE1
-
Eltrombopag Treatment of Thrombocytopenia in Subjects With Advanced Myelodysplastic Syndrome (MDS) or Secondary Acute Myeloid Leukemia After MDS (sAML/MDS)
NCT00903422 ·Status: COMPLETED ·Phase: PHASE1
-
LY2510924, Idarubicin and Cytarabine in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT02652871 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Participants With Acute Leukemia
NCT01214603 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)
NCT05829226 ·Status: COMPLETED ·Phase: PHASE1
-
Feasibility Study to Evaluate Outpatient Blinatumomab in Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL)
NCT04506086 ·Status: TERMINATED ·Phase: PHASE4
-
A Long-Term Study of the Effects of Orally Administered SAR302503 in Patients With Myelofibrosis
NCT00724334 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic Syndrome
NCT01795924 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of [18F]LY4214835 in Healthy Volunteers and Participants With Cancer
NCT07258836 ·Status: RECRUITING ·Phase: PHASE1
-
Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALL
NCT04524455 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With IPSS-R Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS).
NCT03946670 ·Status: TERMINATED ·Phase: PHASE2
-
Monoclonal Antibody Therapy in Treating Patients With Myelodysplastic Syndrome or Relapsed or Refractory Acute Myeloid Leukemia or Chronic Myelogenous Leukemia
NCT00002890 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF
NCT01787552 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)
NCT04551066 ·Status: TERMINATED ·Phase: PHASE3
-
LY3214996 in Patients With AML Who Are Not Candidates for Standard Therapy
NCT04081259 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY3410738 in Healthy Adult Participants
NCT06181045 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis
NCT01730248 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors
NCT02597036 ·Status: TERMINATED ·Phase: PHASE1
-
Multiple Ascending Dose of BMS-911543
NCT01236352 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of Lintuzumab (SGN-33) in Combination With Low Dose Cytarabine in Patients 60+ Years With AML
NCT00528333 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis
NCT02737202 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia
NCT02011945 ·Status: COMPLETED ·Phase: PHASE1
-
CMC-544 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL)
NCT01134575 ·Status: COMPLETED ·Phase: PHASE2