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Low Dose Effects of X-rays in Pediatric Patients Undergoing a CT Examination.

NCT01518673 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2021-11-19

No results posted yet for this study

Summary

Patients undergoing a computed tomography are exposed to a relatively high dose of X-rays. Pediatric patients are known to be very radiosensitive with respect to radiation induced cancer. Using the technique of scoring γ-H2AX foci in peripheral blood lymphocytes the most important lesions to the genetic material DNA, double strand breaks induced by CT X-rays can be detected. The technique will be applied in a multicenter setting for evaluation of X-effects induced by a computed tomography examination in a population of pediatric patients. To this end a blood sample will be taken from the patients before and after the examination.

Conditions

  • Pediatric Patients Undergoing a Computed Tomography Examination

Interventions

PROCEDURE

Blood test

Analysing X-ray induced genetic effects in pediatric patients directly after a computer tomography scan.

Sponsors & Collaborators

  • Federal Agency for Nuclear Control, Belgium

    collaborator OTHER_GOV

  • University Ghent

    lead OTHER

Principal Investigators

  • Peter Smeets, MD · University Hospital, Ghent

Eligibility

Max Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2015-01-31
Completion
2015-06-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01518673 on ClinicalTrials.gov