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Dynamic Contrast Enhanced (DCE)-MRI in Fibromyalgia

NCT01506817 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2012-01-10

No results posted yet for this study

Summary

The primary objective of the current pilot study is to analyze MRI contrast-enhancement patterns in the hands of patients with fibromyalgia as compared to the findings in healthy controls. Further, to compare enhancement patterns obtained in fibromyalgia patients with those described in inflammatory joint disorders, i.e. rheumatoid arthritis and psoriatic arthritis.

Hypothesis:

Dynamic contrast-enhanced MRI (DCE-MRI) of the hands in patients with fibromyalgia reveals pathological imaging patterns indicative of diffuse non-arthrogenic inflammation of e.g. superficial soft tissues and /or muscle with patterns distinct from those of inflammatory joint disorders e.g. rheumatoid arthritis and psoriatic arthritis.

Conditions

  • Fibromyalgia

Interventions

PROCEDURE

Dynamic contrast-enhanced MRI of the hands

The hand and wrist will be examined in a 3T Siemens Verio® MR scanner with the patients and normal controls supine and the hand along the side of the body (3T Verio) using a semiflex 15 channel body coil. Total imaging time varies between 30-35 minutes.

Sponsors & Collaborators

  • Oak Foundation

    collaborator OTHER

  • Frederiksberg University Hospital

    lead OTHER

Principal Investigators

  • Mikael Boesen, MD,PhD · The Parker Institute and Department of Radiology, Frederiksberg Hospital Denmark

  • Henning Bliddal, Professor, DMSci · The Parker Institute, Frederiksberg Hospital Denmark

  • Kirstine Amris, MD · The Parker Institute and Department of Rheumatology, Frederiksberg Hospital Denmark

  • Peter Taylor, Professor, MA, PhD · Kennedy Institute of Rheumatology, University of Oxford, England

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2012-09-30
Completion
2012-09-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01506817 on ClinicalTrials.gov