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Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography

NCT01479790 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2013-02-21

No results posted yet for this study

Summary

Dry eye is a common condition that affects vision and quality of life in patients. Dry eye clinical research is limited to follow up of disease progression. Currently, most research outcomes are based on subjective patient complaints rather than objective assessment of the condition. Only few objective measurements for dry eye are available today and this is mainly the result of poor repeatability and inaccuracy.

This current study aims to evaluate 2 new non-invasive imaging techniques suitable for dry eye assessment.

Anterior segment optical coherence tomography (AS-OCT) is an imaging device that has the ability to image the tear meniscus of the eye in a safe and non-invasive manner. Image analysis can then indirectly determine the tear film volume. Improvements in the image resolution of these devices require a study that compares the repeatability and agreement of an older (Visante AS-OCT) and a newer instrument (Cirrus AS-OCT) which the current study aims to address.

Another method of evaluating dry eye disease is a novel technique that uses functional infrared thermography to measure tear evaporation rate. This study will also establish repeatability of measurements of the ocular surface temperature which are used to calculate tear evaporation rates.

Should these methods are found to be repeatable, they can be used in future clinical trials as an additional tool to investigate dry eye treatments.

Conditions

  • Dry Eye Syndromes

Interventions

DEVICE

EyeGiene

The eye mask with a temperature of not more than 40 deg C (confirmed by thermometer) will be worn by the volunteer for 5 minutes.

Sponsors & Collaborators

  • Singapore Eye Research Institute

    collaborator OTHER

  • Nanchang University

    collaborator OTHER

  • Singapore National Eye Centre

    lead OTHER_GOV

Principal Investigators

  • Louis Tong, PhD · Singapore National Eye Centre

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-06-30
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01479790 on ClinicalTrials.gov