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Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation

NCT01448356 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2012-12-12

Study results available
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Summary

Dry eye and ocular surface disease account for a lot of morbidity and socio-economic burden in Asia and the rest of the world. This is a small pilot study to evaluate tear function under different conditions of humidity and temperature. This data will be useful for designing future trials in ocular surface and dry eye. The data will likely be used to propose a larger national funded project involving clinical trials. This study involves collaboration between engineers, ocular surface clinicians as well as specialists from the defence science organisation. When successfully completed, the project will increase the capability of Singapore Eye Research Institute and Singapore National Eye Centre to support future industry and academic research in the ocular surface.

Conditions

  • Environmental Exposure

Interventions

PROCEDURE

temperature and humidity

The volunteer is exposed to a controlled environment with a chamber setting of: 1. 25°C and 45% humidity; 2. 25°C and 65% humidity; 3. 30°C and 45% humidity; 4. 30°C and 65% humidity After an adaptation period of at least 20 minutes, participants underwent measurements of tear evaporation and tear film break up time. After collection of data, the chamber settings were adjusted to the next condition.

Sponsors & Collaborators

  • Singapore National Eye Centre

    collaborator OTHER_GOV

  • Singapore Eye Research Institute

    lead OTHER

Principal Investigators

  • Andrea Petznick, PhD · Singapore Eye Research Institute

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2012-04-30
Completion
2012-04-30

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01448356 on ClinicalTrials.gov