Trial Outcomes & Findings for Does Nesiritide Provide Renal Protection (NCT NCT01440881)
NCT ID: NCT01440881
Last Updated: 2014-06-06
Results Overview
0.35 mL of whole blood from each patient was applied to a microfluidics chip to isolate neutrophils. Total RNA was subsequently isolated and gene expression (for all genes listed below) was measured with an Affymetrix gene chip. Data was normalized using RMA (Robust multi-array average) and expressed as log2 expression.
Recruitment status
COMPLETED
Study phase
PHASE2
Target enrollment
37 participants
Primary outcome timeframe
30 days from the start of infusion
Results posted on
2014-06-06
Participant Flow
Starting in June 2010 and ending in December 2012, subjects were seen in outpatient clinics or in the hospital. The pre-operative labs were used to screen and enroll subjects.
Out of the 37 signed informed consent there were 8 subjects who were consented and did not participate: 2 subjects changed their mind, 5 subjects creatinine level was not within the protocol level for participation, 1 subject surgery was canceled. This left 29 subjects to participate in the study.
Participant milestones
| Measure |
Nesiritide
infuses at 0.01 micrograms (MCG)/kilograms (KG)/minute (min) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
infuses at 0.01micrograms (MCG)/kilograms (KG)/minute (min) for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
Overall Study
STARTED
|
14
|
15
|
|
Overall Study
COMPLETED
|
14
|
14
|
|
Overall Study
NOT COMPLETED
|
0
|
1
|
Reasons for withdrawal
| Measure |
Nesiritide
infuses at 0.01 micrograms (MCG)/kilograms (KG)/minute (min) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
infuses at 0.01micrograms (MCG)/kilograms (KG)/minute (min) for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
Overall Study
Death
|
0
|
1
|
Baseline Characteristics
Does Nesiritide Provide Renal Protection
Baseline characteristics by cohort
| Measure |
Nesiritide
n=14 Participants
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 Participants
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
Total
n=29 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
4 Participants
n=99 Participants
|
9 Participants
n=107 Participants
|
13 Participants
n=206 Participants
|
|
Age, Categorical
>=65 years
|
10 Participants
n=99 Participants
|
6 Participants
n=107 Participants
|
16 Participants
n=206 Participants
|
|
Sex: Female, Male
Female
|
5 Participants
n=99 Participants
|
5 Participants
n=107 Participants
|
10 Participants
n=206 Participants
|
|
Sex: Female, Male
Male
|
9 Participants
n=99 Participants
|
10 Participants
n=107 Participants
|
19 Participants
n=206 Participants
|
|
Region of Enrollment
United States
|
14 participants
n=99 Participants
|
15 participants
n=107 Participants
|
29 participants
n=206 Participants
|
PRIMARY outcome
Timeframe: 30 days from the start of infusion0.35 mL of whole blood from each patient was applied to a microfluidics chip to isolate neutrophils. Total RNA was subsequently isolated and gene expression (for all genes listed below) was measured with an Affymetrix gene chip. Data was normalized using RMA (Robust multi-array average) and expressed as log2 expression.
Outcome measures
| Measure |
Nesiritide
n=14 Participants
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 Participants
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOXHD1
|
6.886 log2 expression
Standard Deviation 0.336
|
6.742 log2 expression
Standard Deviation 0.398
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: DYM
|
8.158 log2 expression
Standard Deviation 0.241
|
8.088 log2 expression
Standard Deviation 0.281
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: Q6ZU44_HUMAN
|
4.953 log2 expression
Standard Deviation 0.200
|
4.751 log2 expression
Standard Deviation 0.159
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: TUFT1
|
5.453 log2 expression
Standard Deviation 0.251
|
5.630 log2 expression
Standard Deviation 0.195
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: IL23A
|
4.508 log2 expression
Standard Deviation 0.177
|
4.546 log2 expression
Standard Deviation 0.301
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: C6orf145
|
5.501 log2 expression
Standard Deviation 0.216
|
5.444 log2 expression
Standard Deviation 0.156
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: HIST1H1C
|
8.888 log2 expression
Standard Deviation 0.506
|
9.404 log2 expression
Standard Deviation 0.903
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: TBC1D26 /// ZNF286A
|
4.990 log2 expression
Standard Deviation 0.092
|
4.930 log2 expression
Standard Deviation 0.113
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: RPL27
|
9.269 log2 expression
Standard Deviation 0.191
|
9.315 log2 expression
Standard Deviation 0.214
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC440087
|
3.553 log2 expression
Standard Deviation 0.181
|
3.647 log2 expression
Standard Deviation 0.218
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: PRAMEF8
|
5.828 log2 expression
Standard Deviation 0.232
|
5.856 log2 expression
Standard Deviation 0.233
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: RPL26
|
7.440 log2 expression
Standard Deviation 0.205
|
7.481 log2 expression
Standard Deviation 0.212
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: OXT
|
6.899 log2 expression
Standard Deviation 0.175
|
6.884 log2 expression
Standard Deviation 0.102
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: GIPC3
|
6.158 log2 expression
Standard Deviation 0.124
|
6.097 log2 expression
Standard Deviation 0.114
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: ZNF540
|
4.284 log2 expression
Standard Deviation 0.110
|
4.255 log2 expression
Standard Deviation 0.120
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: FAM98C
|
6.778 log2 expression
Standard Deviation 0.146
|
6.857 log2 expression
Standard Deviation 0.129
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: PTOV1
|
8.234 log2 expression
Standard Deviation 0.210
|
8.153 log2 expression
Standard Deviation 0.149
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: RPS16
|
9.077 log2 expression
Standard Deviation 0.195
|
9.012 log2 expression
Standard Deviation 0.221
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: ERCC1
|
5.798 log2 expression
Standard Deviation 0.171
|
5.843 log2 expression
Standard Deviation 0.242
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC339344
|
7.522 log2 expression
Standard Deviation 0.238
|
7.502 log2 expression
Standard Deviation 0.164
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: ATG10
|
5.347 log2 expression
Standard Deviation 0.390
|
5.286 log2 expression
Standard Deviation 0.308
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: SLC35C1
|
6.422 log2 expression
Standard Deviation 0.155
|
6.358 log2 expression
Standard Deviation 0.188
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: PTPMT1 /// NDUFS3 /// PTPMT1
|
6.702 log2 expression
Standard Deviation 0.168
|
6.706 log2 expression
Standard Deviation 0.177
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: SIDT2
|
6.792 log2 expression
Standard Deviation 0.215
|
6.870 log2 expression
Standard Deviation 0.161
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: Q6ZVY8_HUMAN
|
5.229 log2 expression
Standard Deviation 0.124
|
5.132 log2 expression
Standard Deviation 0.214
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: CECR5
|
5.519 log2 expression
Standard Deviation 0.108
|
5.499 log2 expression
Standard Deviation 0.105
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: VPS35
|
9.042 log2 expression
Standard Deviation 0.339
|
8.974 log2 expression
Standard Deviation 0.379
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LGALS2
|
5.513 log2 expression
Standard Deviation 0.174
|
5.565 log2 expression
Standard Deviation 0.187
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: NDUFA6
|
6.496 log2 expression
Standard Deviation 0.334
|
6.680 log2 expression
Standard Deviation 0.455
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC497190 /// NP_001011880.1
|
6.469 log2 expression
Standard Deviation 0.089
|
6.470 log2 expression
Standard Deviation 0.116
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: CXorf52
|
6.151 log2 expression
Standard Deviation 0.480
|
6.301 log2 expression
Standard Deviation 0.387
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: MAP4K4
|
10.656 log2 expression
Standard Deviation 0.121
|
10.651 log2 expression
Standard Deviation 0.159
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC441241 /// VKORC1L1
|
6.418 log2 expression
Standard Deviation 0.349
|
6.533 log2 expression
Standard Deviation 0.453
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: DBF4
|
4.706 log2 expression
Standard Deviation 0.245
|
4.776 log2 expression
Standard Deviation 0.364
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: SP100
|
9.074 log2 expression
Standard Deviation 0.242
|
9.205 log2 expression
Standard Deviation 0.191
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: TPT1
|
9.177 log2 expression
Standard Deviation 0.139
|
9.242 log2 expression
Standard Deviation 0.125
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC285908
|
7.517 log2 expression
Standard Deviation 0.173
|
7.454 log2 expression
Standard Deviation 0.322
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: BAZ2B
|
8.802 log2 expression
Standard Deviation 0.330
|
8.811 log2 expression
Standard Deviation 0.117
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: GRM8
|
4.303 log2 expression
Standard Deviation 0.114
|
4.259 log2 expression
Standard Deviation 0.142
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: Q6ZP42_HUMAN
|
4.967 log2 expression
Standard Deviation 0.251
|
5.040 log2 expression
Standard Deviation 0.336
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: HTR2B
|
4.337 log2 expression
Standard Deviation 0.263
|
4.037 log2 expression
Standard Deviation 0.289
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: PRSS3
|
6.338 log2 expression
Standard Deviation 0.123
|
6.241 log2 expression
Standard Deviation 0.118
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC728449 /// ANXA8L2
|
5.755 log2 expression
Standard Deviation 0.105
|
5.801 log2 expression
Standard Deviation 0.195
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: RPS24
|
7.029 log2 expression
Standard Deviation 0.153
|
7.063 log2 expression
Standard Deviation 0.153
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: DOLPP1
|
5.707 log2 expression
Standard Deviation 0.218
|
5.759 log2 expression
Standard Deviation 0.200
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: UBQLN1
|
9.129 log2 expression
Standard Deviation 0.174
|
9.172 log2 expression
Standard Deviation 0.214
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: TNFSF15
|
5.080 log2 expression
Standard Deviation 0.296
|
5.072 log2 expression
Standard Deviation 0.330
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: Q5QFB9_HUMAN
|
4.770 log2 expression
Standard Deviation 0.456
|
4.430 log2 expression
Standard Deviation 0.427
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: CYP19A1
|
3.696 log2 expression
Standard Deviation 0.126
|
3.725 log2 expression
Standard Deviation 0.131
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: Q6UWF5_HUMAN
|
3.851 log2 expression
Standard Deviation 0.309
|
3.893 log2 expression
Standard Deviation 0.209
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: LOC340204 /// NP_001010886.1
|
4.453 log2 expression
Standard Deviation 0.208
|
4.437 log2 expression
Standard Deviation 0.273
|
|
Measure Neutrophils to Measure Kidney Injury
Gene: CCDC76
|
3.702 log2 expression
Standard Deviation 0.211
|
3.627 log2 expression
Standard Deviation 0.211
|
PRIMARY outcome
Timeframe: 30 days from the start of infusionPopulation: randomized per protocol
Serial measurement of serum cytokine profiles were measured with multiplex Luminex plates that enable the simultaneous measurement of 23 cytokines.
Outcome measures
| Measure |
Nesiritide
n=14 Participants
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 Participants
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 baseline
|
1.750 pg/ml
Interval 0.407 to 7.189
|
1.959 pg/ml
Interval 0.433 to 9.273
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 time point 0
|
28.167 pg/ml
Interval 18.008 to 40.283
|
63.930 pg/ml
Interval 49.471 to 99.201
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 1 hour post bypass
|
33.457 pg/ml
Interval 24.237 to 48.103
|
57.412 pg/ml
Interval 40.169 to 120.589
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 2 hour post bypass
|
44.383 pg/ml
Interval 35.629 to 62.855
|
43.523 pg/ml
Interval 35.38 to 118.481
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 4hour post bypass
|
35.759 pg/ml
Interval 30.562 to 72.392
|
37.967 pg/ml
Interval 27.729 to 78.084
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 6 hour post bypass
|
28.593 pg/ml
Interval 24.19 to 52.719
|
27.840 pg/ml
Interval 19.707 to 56.711
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 8 hours post bypass
|
29.794 pg/ml
Interval 21.559 to 46.56
|
21.673 pg/ml
Interval 14.773 to 44.934
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-6 24 hours post bypas
|
29.513 pg/ml
Interval 20.704 to 35.399
|
34.650 pg/ml
Interval 24.828 to 41.952
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8 baseline
|
5.377 pg/ml
Interval 3.554 to 10.042
|
5.238 pg/ml
Interval 2.621 to 9.596
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-8 0 time point
|
16.821 pg/ml
Interval 13.256 to 31.274
|
18.962 pg/ml
Interval 13.751 to 35.247
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8- 1 hour post bypass
|
17.107 pg/ml
Interval 14.959 to 23.696
|
20.873 pg/ml
Interval 14.384 to 42.45
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8-2 hour post bypass
|
17.068 pg/ml
Interval 15.574 to 34.241
|
23.607 pg/ml
Interval 14.957 to 36.67
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8 4 hour post bypass
|
16.005 pg/ml
Interval 14.241 to 23.305
|
17.627 pg/ml
Interval 15.373 to 26.853
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8 6 hour post bypass
|
14.290 pg/ml
Interval 12.09 to 23.91
|
19.880 pg/ml
Interval 12.237 to 24.394
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8 8hour post bypass
|
14.550 pg/ml
Interval 11.221 to 19.53
|
16.282 pg/ml
Interval 9.661 to 19.578
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL8 24 hour post bypass
|
12.264 pg/ml
Interval 9.647 to 16.549
|
14.600 pg/ml
Interval 10.591 to 16.596
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL10 baseline
|
8.063 pg/ml
Interval 2.93 to 23.735
|
9.130 pg/ml
Interval 8.056 to 14.72
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL10 0 time point
|
1289.776 pg/ml
Interval 665.231 to 1691.249
|
2206.177 pg/ml
Interval 1666.118 to 2748.541
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL 10 1 hour post bypass
|
1558.903 pg/ml
Interval 1169.255 to 2519.783
|
2074.906 pg/ml
Interval 1196.237 to 2482.497
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL10 2 hour post bypass
|
667.765 pg/ml
Interval 549.079 to 918.143
|
844.352 pg/ml
Interval 406.264 to 1097.627
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL 10 4 hour post bypass
|
309.351 pg/ml
Interval 213.114 to 450.841
|
230.101 pg/ml
Interval 134.756 to 470.378
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL 10 6 hour post bypass
|
107.778 pg/ml
Interval 81.076 to 231.203
|
95.925 pg/ml
Interval 81.336 to 262.041
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL 10 8 hour post bypass
|
103.791 pg/ml
Interval 70.919 to 174.66
|
84.070 pg/ml
Interval 65.525 to 93.98
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL 10 24 hour post bypass
|
18.597 pg/ml
Interval 10.61 to 29.888
|
34.862 pg/ml
Interval 23.83 to 44.29
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha baseline
|
6.286 pg/ml
Interval 4.961 to 7.346
|
5.402 pg/ml
Interval 3.009 to 8.012
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 0 time point
|
8.253 pg/ml
Interval 6.526 to 9.649
|
7.795 pg/ml
Interval 5.688 to 11.36
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 1hour post bypass
|
10.729 pg/ml
Interval 9.265 to 12.63
|
13.310 pg/ml
Interval 8.519 to 15.58
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 2 hour post bypass
|
9.855 pg/ml
Interval 8.885 to 11.307
|
11.729 pg/ml
Interval 9.975 to 13.947
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 4 hour post bypass
|
8.843 pg/ml
Interval 7.002 to 13.359
|
9.291 pg/ml
Interval 6.509 to 13.568
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 6 hour post bypass
|
7.185 pg/ml
Interval 5.607 to 11.008
|
7.953 pg/ml
Interval 4.84 to 10.815
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 8 hour post bypass
|
5.175 pg/ml
Interval 4.284 to 8.931
|
5.212 pg/ml
Interval 2.8 to 6.25
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF alpha 24 hour post bypass
|
4.620 pg/ml
Interval 1.971 to 6.091
|
4.525 pg/ml
Interval 3.365 to 6.618
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta baseline
|
1.162 pg/ml
Interval 0.0 to 7.714
|
0.056 pg/ml
Interval 0.0 to 1.623
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 0 time point
|
1.110 pg/ml
Interval 0.055 to 8.519
|
0.000 pg/ml
Interval 0.0 to 1.031
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 1 hour post bypass
|
0.898 pg/ml
Interval 0.0 to 8.648
|
0.000 pg/ml
Interval 0.0 to 0.338
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 2 hour post bypass
|
1.302 pg/ml
Interval 0.198 to 6.717
|
0.406 pg/ml
Interval 0.0 to 0.95
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 4 hour post bypass
|
1.698 pg/ml
Interval 0.518 to 5.051
|
0.074 pg/ml
Interval 0.0 to 0.706
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 6 hour post bypass
|
1.234 pg/ml
Interval 0.149 to 5.796
|
0.219 pg/ml
Interval 0.0 to 0.498
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 8 hour post bypass
|
1.389 pg/ml
Interval 0.198 to 4.883
|
0.058 pg/ml
Interval 0.0 to 1.199
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
TNF beta 24 hour post bypass
|
0.309 pg/ml
Interval 0.0 to 8.662
|
0.404 pg/ml
Interval 0.0 to 1.589
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF baseline
|
102.054 pg/ml
Interval 41.148 to 151.786
|
44.971 pg/ml
Interval 33.233 to 78.745
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 0 time point
|
70.647 pg/ml
Interval 27.779 to 121.082
|
35.773 pg/ml
Interval 28.314 to 57.292
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 1 hour post bypass
|
89.814 pg/ml
Interval 48.225 to 157.629
|
48.928 pg/ml
Interval 20.45 to 67.083
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 2 hour post bypass
|
91.881 pg/ml
Interval 50.242 to 153.212
|
41.695 pg/ml
Interval 22.994 to 93.293
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 4 hour poswt bypass
|
88.005 pg/ml
Interval 43.21 to 161.897
|
30.529 pg/ml
Interval 19.981 to 68.473
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 6 hour post bypass
|
83.581 pg/ml
Interval 42.65 to 144.648
|
26.226 pg/ml
Interval 24.178 to 56.9
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 8 hour post bypass
|
84.494 pg/ml
Interval 39.215 to 137.66
|
36.577 pg/ml
Interval 28.953 to 70.361
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
VEGF 24 hour post bypass
|
76.771 pg/ml
Interval 43.973 to 121.778
|
64.660 pg/ml
Interval 29.898 to 98.724
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 baseline
|
174.848 pg/ml
Interval 143.677 to 215.191
|
182.708 pg/ml
Interval 146.434 to 250.832
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 0 timepoint
|
478.742 pg/ml
Interval 381.513 to 650.308
|
455.129 pg/ml
Interval 315.69 to 678.396
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 1 hour post bypass
|
483.095 pg/ml
Interval 408.87 to 822.554
|
572.955 pg/ml
Interval 429.401 to 955.947
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 2 hour post bypass
|
441.203 pg/ml
Interval 318.854 to 709.902
|
502.992 pg/ml
Interval 429.098 to 912.456
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 4 hour post bypass
|
265.736 pg/ml
Interval 211.247 to 432.764
|
325.249 pg/ml
Interval 288.906 to 392.275
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 6 hour post bypass
|
191.735 pg/ml
Interval 168.518 to 310.851
|
218.561 pg/ml
Interval 195.837 to 311.979
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 8 hour post bypass
|
180.749 pg/ml
Interval 128.801 to 232.952
|
177.527 pg/ml
Interval 149.096 to 239.253
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MCP-1 24 hour post bypass
|
202.621 pg/ml
Interval 159.322 to 236.815
|
215.708 pg/ml
Interval 162.058 to 247.327
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF baseline
|
47.564 pg/ml
Interval 28.196 to 75.165
|
39.794 pg/ml
Interval 26.826 to 74.659
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 0 timepoint
|
31.242 pg/ml
Interval 14.718 to 69.982
|
21.983 pg/ml
Interval 15.145 to 47.203
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 1 hour post bypass
|
35.745 pg/ml
Interval 21.122 to 79.986
|
19.395 pg/ml
Interval 14.549 to 33.21
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 2 hour post bypass
|
24.052 pg/ml
Interval 17.339 to 56.405
|
23.662 pg/ml
Interval 12.757 to 29.182
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 4 hour post bypass
|
29.841 pg/ml
Interval 15.028 to 48.199
|
19.141 pg/ml
Interval 11.353 to 23.873
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 6 hour post bypass
|
33.050 pg/ml
Interval 15.711 to 44.114
|
22.655 pg/ml
Interval 15.988 to 28.37
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 8 post bypass
|
27.022 pg/ml
Interval 12.558 to 47.269
|
26.093 pg/ml
Interval 16.129 to 36.236
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
EGF 24 hour post bypass
|
30.494 pg/ml
Interval 13.189 to 63.895
|
17.768 pg/ml
Interval 15.228 to 54.487
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha baseline
|
12.372 pg/ml
Interval 4.209 to 26.931
|
2.754 pg/ml
Interval 0.938 to 17.26
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 0 time
|
41.216 pg/ml
Interval 20.491 to 49.241
|
31.597 pg/ml
Interval 15.75 to 32.969
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 1 hour post bypass
|
26.101 pg/ml
Interval 10.389 to 43.738
|
21.069 pg/ml
Interval 8.055 to 29.453
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 2 hour post bypass
|
22.122 pg/ml
Interval 12.403 to 36.62
|
17.803 pg/ml
Interval 6.43 to 25.311
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 4 hour post bypass
|
18.137 pg/ml
Interval 14.394 to 25.199
|
10.732 pg/ml
Interval 3.549 to 17.785
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 6 hour post bypass
|
15.148 pg/ml
Interval 7.747 to 24.294
|
5.745 pg/ml
Interval 2.233 to 16.9
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 8 hour post bypass
|
9.334 pg/ml
Interval 4.901 to 21.816
|
5.376 pg/ml
Interval 1.093 to 10.69
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1 alpha 24 hour post bypass
|
2.974 pg/ml
Interval 1.426 to 19.918
|
1.389 pg/ml
Interval 0.0 to 9.465
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta baseline
|
1.014 pg/ml
Interval 0.0 to 2.938
|
0.394 pg/ml
Interval 0.0 to 1.227
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 0 time point
|
0.775 pg/ml
Interval 0.0 to 2.599
|
0.492 pg/ml
Interval 0.0 to 0.775
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 1 hour post bypass
|
0.653 pg/ml
Interval 0.015 to 3.005
|
0.430 pg/ml
Interval 0.0 to 1.252
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 2 hour post bypass
|
1.311 pg/ml
Interval 0.001 to 3.051
|
0.450 pg/ml
Interval 0.0 to 1.411
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 4 hour post bypass
|
1.716 pg/ml
Interval 0.155 to 2.256
|
0.310 pg/ml
Interval 0.0 to 1.349
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 6 hour post bypass
|
1.119 pg/ml
Interval 0.0 to 2.531
|
0.366 pg/ml
Interval 0.0 to 1.237
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 8 hour post bypass
|
0.875 pg/ml
Interval 0.0 to 2.022
|
0.462 pg/ml
Interval 0.0 to 0.946
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1Beta 24 hour post bypass
|
0.000 pg/ml
Interval 0.0 to 1.876
|
0.170 pg/ml
Interval 0.0 to 1.742
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA baseline
|
26.419 pg/ml
Interval 0.0 to 33.138
|
0.000 pg/ml
Interval 0.0 to 21.347
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 0 time point
|
41.945 pg/ml
Interval 14.544 to 96.153
|
53.721 pg/ml
Interval 24.312 to 108.171
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 1 hour post bypass
|
68.792 pg/ml
Interval 13.478 to 112.704
|
71.444 pg/ml
Interval 35.659 to 163.338
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 2 hour post bypass
|
98.089 pg/ml
Interval 65.649 to 227.339
|
237.080 pg/ml
Interval 104.788 to 396.803
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 4 hour post bypass
|
105.861 pg/ml
Interval 48.931 to 173.007
|
152.630 pg/ml
Interval 90.576 to 330.576
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 6 hour post bypass
|
67.705 pg/ml
Interval 31.982 to 141.879
|
75.226 pg/ml
Interval 30.186 to 128.904
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 8 hour post bypass
|
45.097 pg/ml
Interval 3.338 to 70.559
|
27.442 pg/ml
Interval 14.928 to 120.969
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-1RA 24 hour post bypass
|
21.181 pg/ml
Interval 0.0 to 38.018
|
15.765 pg/ml
Interval 0.0 to 38.997
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 baseline
|
0.850 pg/ml
Interval 0.027 to 3.993
|
0.068 pg/ml
Interval 0.0 to 1.008
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 0 timepoint
|
1.130 pg/ml
Interval 0.126 to 3.741
|
0.401 pg/ml
Interval 0.0 to 1.189
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 1 hour post bypass
|
1.714 pg/ml
Interval 0.069 to 3.466
|
0.059 pg/ml
Interval 0.0 to 1.352
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 2 hour post bypass
|
1.714 pg/ml
Interval 0.43 to 4.723
|
1.110 pg/ml
Interval 0.054 to 2.04
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 4 hour post bypass
|
1.753 pg/ml
Interval 0.685 to 3.601
|
0.870 pg/ml
Interval 0.086 to 1.939
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 6 hour post bypass
|
1.297 pg/ml
Interval 0.215 to 3.952
|
0.923 pg/ml
Interval 0.045 to 1.433
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 8 hour post bypass
|
1.281 pg/ml
Interval 0.198 to 2.792
|
0.599 pg/ml
Interval 0.03 to 1.271
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-2 24 hour post bypass
|
0.921 pg/ml
Interval 0.0 to 2.495
|
0.172 pg/ml
Interval 0.0 to 1.039
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 baseline
|
0.093 pg/ml
Interval 0.0 to 0.552
|
0.000 pg/ml
Interval 0.0 to 0.292
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 0 timepoint
|
0.185 pg/ml
Interval 0.0 to 0.544
|
0.000 pg/ml
Interval 0.0 to 0.196
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 1 hour post bypass
|
0.000 pg/ml
Interval 0.0 to 0.41
|
0.000 pg/ml
Interval 0.0 to 0.2
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 2 hour post bypass
|
0.000 pg/ml
Interval 0.0 to 0.355
|
0.000 pg/ml
Interval 0.0 to 0.258
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 4 hour post bypass
|
0.000 pg/ml
Interval 0.0 to 0.372
|
0.000 pg/ml
Interval 0.0 to 0.191
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL_3 6 hour post bypass
|
0.061 pg/ml
Interval 0.0 to 0.377
|
0.000 pg/ml
Interval 0.0 to 0.217
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-3 8 hour post bypass
|
0.061 pg/ml
Interval 0.0 to 0.293
|
0.000 pg/ml
Interval 0.0 to 0.199
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL_3 24 hour post bypass
|
0.073 pg/ml
Interval 0.0 to 0.445
|
0.000 pg/ml
Interval 0.0 to 0.234
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 baseline
|
4.295 pg/ml
Interval 0.717 to 19.395
|
0.166 pg/ml
Interval 0.0 to 2.459
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 0 timepoint
|
6.285 pg/ml
Interval 0.084 to 10.721
|
0.359 pg/ml
Interval 0.0 to 1.944
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 1 hour post bypass
|
6.221 pg/ml
Interval 1.321 to 12.502
|
0.414 pg/ml
Interval 0.0 to 2.437
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL_4 2 hour post bypass
|
5.534 pg/ml
Interval 3.03 to 10.564
|
1.381 pg/ml
Interval 0.139 to 3.258
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 4 hour post bypass
|
6.743 pg/ml
Interval 1.647 to 10.309
|
0.958 pg/ml
Interval 0.0 to 3.584
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 6 hour post bypass
|
4.859 pg/ml
Interval 2.256 to 8.644
|
0.746 pg/ml
Interval 0.0 to 2.877
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-4 8 hour post bypass
|
4.063 pg/ml
Interval 1.329 to 7.17
|
0.000 pg/ml
Interval 0.0 to 2.378
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL_4 24 hour post bypass
|
3.634 pg/ml
Interval 0.0 to 8.419
|
0.000 pg/ml
Interval 0.0 to 1.864
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 baseline
|
0.563 pg/ml
Interval 0.0 to 4.234
|
0.353 pg/ml
Interval 0.0 to 1.233
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 0 timepoint
|
0.134 pg/ml
Interval 0.0 to 0.808
|
0.016 pg/ml
Interval 0.0 to 0.58
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 1 hour post bypass
|
0.169 pg/ml
Interval 0.0 to 1.145
|
0.040 pg/ml
Interval 0.0 to 0.789
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 2 hour post bypass
|
0.291 pg/ml
Interval 0.0 to 0.901
|
0.000 pg/ml
Interval 0.0 to 1.104
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 4 hour post bypass
|
0.626 pg/ml
Interval 0.0 to 1.089
|
0.016 pg/ml
Interval 0.0 to 1.083
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 6 hour post bypass
|
0.334 pg/ml
Interval 0.0 to 1.252
|
0.210 pg/ml
Interval 0.0 to 0.9
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 8 hour post bypass
|
0.387 pg/ml
Interval 0.02 to 0.574
|
0.431 pg/ml
Interval 0.0 to 0.796
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-5 24 hour post bypass
|
0.373 pg/ml
Interval 0.0 to 1.366
|
0.503 pg/ml
Interval 0.055 to 0.794
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 baseline
|
4.032 pg/ml
Interval 3.525 to 4.584
|
2.987 pg/ml
Interval 1.617 to 3.672
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 0 timepoint
|
3.673 pg/ml
Interval 2.62 to 6.634
|
4.311 pg/ml
Interval 2.539 to 5.931
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 1 hour post bypass
|
2.973 pg/ml
Interval 2.0 to 4.488
|
1.822 pg/ml
Interval 1.483 to 4.524
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 2 hour post bypass
|
2.469 pg/ml
Interval 1.965 to 4.588
|
2.104 pg/ml
Interval 1.187 to 4.43
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 4 hour post bypass
|
3.061 pg/ml
Interval 2.245 to 4.719
|
2.530 pg/ml
Interval 1.377 to 3.134
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 6 hour post bypass
|
3.391 pg/ml
Interval 2.527 to 4.717
|
2.317 pg/ml
Interval 1.509 to 3.027
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 8 hour post bypass
|
3.506 pg/ml
Interval 1.769 to 4.277
|
2.354 pg/ml
Interval 1.655 to 4.597
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-7 24 hour post bypass
|
3.656 pg/ml
Interval 0.0 to 4.629
|
4.097 pg/ml
Interval 1.163 to 5.022
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 baseline
|
0.922 pg/ml
Interval 0.0 to 11.185
|
0.000 pg/ml
Interval 0.0 to 2.027
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 0 timepoint
|
0.133 pg/ml
Interval 0.0 to 4.913
|
0.000 pg/ml
Interval 0.0 to 0.302
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 1 hour post bypass
|
0.719 pg/ml
Interval 0.0 to 5.817
|
0.000 pg/ml
Interval 0.0 to 0.989
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 2 hour post bypass
|
2.352 pg/ml
Interval 0.0 to 4.561
|
1.185 pg/ml
Interval 0.0 to 1.794
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 4 hour post bypass
|
1.571 pg/ml
Interval 0.0 to 3.443
|
0.287 pg/ml
Interval 0.0 to 1.029
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 6 hour post bypass
|
1.138 pg/ml
Interval 0.0 to 5.16
|
0.000 pg/ml
Interval 0.0 to 0.746
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 8 hour post bypass
|
0.786 pg/ml
Interval 0.0 to 2.603
|
0.000 pg/ml
Interval 0.0 to 0.573
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-13 24 hour post bypass
|
0.094 pg/ml
Interval 0.0 to 5.222
|
0.000 pg/ml
Interval 0.0 to 1.233
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 baseline
|
1.905 pg/ml
Interval 0.81 to 6.231
|
0.969 pg/ml
Interval 0.0 to 2.795
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 0 timepoint
|
3.200 pg/ml
Interval 1.493 to 6.739
|
3.093 pg/ml
Interval 1.483 to 3.914
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 1 hour post bypass
|
4.228 pg/ml
Interval 2.92 to 7.884
|
3.981 pg/ml
Interval 3.016 to 6.153
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 2 hour post bypass
|
5.556 pg/ml
Interval 2.814 to 8.172
|
4.641 pg/ml
Interval 3.381 to 6.86
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 4 hour post bypass
|
5.723 pg/ml
Interval 4.258 to 7.128
|
4.423 pg/ml
Interval 3.542 to 6.768
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 6 hour post bypass
|
5.021 pg/ml
Interval 3.049 to 7.138
|
4.395 pg/ml
Interval 3.004 to 5.526
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 8 hour post bypass
|
4.984 pg/ml
Interval 2.873 to 6.096
|
3.316 pg/ml
Interval 1.841 to 3.989
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-15 24 hour post bypass
|
6.120 pg/ml
Interval 4.023 to 6.695
|
4.996 pg/ml
Interval 3.434 to 6.161
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 baseline
|
1.171 pg/ml
Interval 0.0 to 2.73
|
0.000 pg/ml
Interval 0.0 to 2.552
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 0 time point
|
0.765 pg/ml
Interval 0.0 to 4.558
|
0.117 pg/ml
Interval 0.0 to 0.943
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 1 hour post bypass
|
2.174 pg/ml
Interval 0.202 to 7.78
|
0.130 pg/ml
Interval 0.0 to 0.768
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 2 hour post bypass
|
1.381 pg/ml
Interval 0.475 to 7.394
|
0.456 pg/ml
Interval 0.0 to 1.228
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 4 hour post bypass
|
1.682 pg/ml
Interval 0.412 to 3.982
|
0.000 pg/ml
Interval 0.0 to 1.899
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 6 hour post bypass
|
0.815 pg/ml
Interval 0.196 to 3.582
|
0.162 pg/ml
Interval 0.0 to 1.29
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL- 17 8 hour post bypass
|
0.817 pg/ml
Interval 0.0 to 2.857
|
0.000 pg/ml
Interval 0.0 to 1.574
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IL-17 24 hour post bypass
|
0.397 pg/ml
Interval 0.0 to 3.457
|
0.0000 pg/ml
Interval 0.0 to 2.48
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 baseline
|
506.657 pg/ml
Interval 490.553 to 713.745
|
475.656 pg/ml
Interval 304.609 to 527.253
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 0 time point
|
2340.935 pg/ml
Interval 1691.645 to 3585.567
|
1790.035 pg/ml
Interval 1554.647 to 3807.319
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 1 hour post bypass
|
1828.152 pg/ml
Interval 1293.335 to 2297.526
|
2298.747 pg/ml
Interval 1478.354 to 2763.464
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 2 hour post bypass
|
1571.877 pg/ml
Interval 1105.554 to 1991.71
|
1365.169 pg/ml
Interval 961.057 to 1998.178
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 4 hour post bypass
|
1072.023 pg/ml
Interval 910.335 to 1338.142
|
855.843 pg/ml
Interval 608.726 to 1465.772
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 6 hour post bypass
|
704.208 pg/ml
Interval 579.992 to 775.662
|
575.429 pg/ml
Interval 396.859 to 1059.186
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 8 hour post bypass
|
448.938 pg/ml
Interval 292.341 to 570.529
|
449.376 pg/ml
Interval 295.222 to 675.398
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
IP-10 24 hour post bypass
|
243.332 pg/ml
Interval 213.669 to 265.925
|
241.467 pg/ml
Interval 157.583 to 333.628
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha baseline
|
2.251 pg/ml
Interval 0.0 to 4.082
|
0.000 pg/ml
Interval 0.0 to 3.064
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 0 time point
|
8.880 pg/ml
Interval 5.954 to 11.191
|
10.109 pg/ml
Interval 4.705 to 14.815
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 1 hour post bypass
|
9.042 pg/ml
Interval 7.056 to 17.518
|
9.182 pg/ml
Interval 6.161 to 18.698
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 2 hour post bypass
|
6.610 pg/ml
Interval 5.41 to 8.129
|
6.268 pg/ml
Interval 4.309 to 10.444
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 4 hour post bypass
|
4.024 pg/ml
Interval 1.888 to 7.931
|
4.309 pg/ml
Interval 0.462 to 4.872
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 6 hour post bypass
|
3.017 pg/ml
Interval 0.154 to 6.573
|
0.870 pg/ml
Interval 0.0 to 2.779
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 8 hour post bypass
|
1.933 pg/ml
Interval 0.0 to 5.446
|
0.000 pg/ml
Interval 0.0 to 3.036
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 alpha 24 hour post bypass
|
1.279 pg/ml
Interval 0.0 to 2.87
|
0.000 pg/ml
Interval 0.0 to 1.806
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta baseline
|
22.626 pg/ml
Interval 19.968 to 33.454
|
18.167 pg/ml
Interval 14.254 to 23.434
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 0 time point
|
55.229 pg/ml
Interval 41.784 to 105.27
|
47.617 pg/ml
Interval 35.62 to 55.731
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 1 hour post bypass
|
85.082 pg/ml
Interval 60.08 to 159.731
|
57.405 pg/ml
Interval 48.3 to 71.806
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 2 hour post bypass
|
53.750 pg/ml
Interval 38.134 to 86.942
|
40.900 pg/ml
Interval 34.678 to 48.173
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 4 hour post bypass
|
34.010 pg/ml
Interval 24.951 to 44.472
|
24.018 pg/ml
Interval 22.72 to 28.116
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 6 hour post bypass
|
26.524 pg/ml
Interval 21.681 to 52.531
|
20.263 pg/ml
Interval 17.094 to 25.972
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 8 hour post bypass
|
22.676 pg/ml
Interval 17.226 to 37.256
|
18.522 pg/ml
Interval 16.173 to 24.292
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
MIP-1 beta 24 hour post bypass
|
18.726 pg/ml
Interval 15.327 to 23.802
|
16.082 pg/ml
Interval 12.354 to 20.734
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF baseline
|
50.953 pg/ml
Interval 31.49 to 81.65
|
43.984 pg/ml
Interval 24.558 to 51.463
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 0 time point
|
92.559 pg/ml
Interval 66.615 to 120.739
|
150.567 pg/ml
Interval 117.98 to 180.159
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 1 hour post bypass
|
124.298 pg/ml
Interval 76.047 to 150.769
|
253.527 pg/ml
Interval 176.006 to 281.092
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 2 hour post bypass
|
249.816 pg/ml
Interval 176.392 to 280.874
|
297.668 pg/ml
Interval 206.217 to 439.136
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 4 hour post bypass
|
285.277 pg/ml
Interval 210.293 to 373.804
|
311.452 pg/ml
Interval 215.692 to 576.031
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 6 hour post bypass
|
252.546 pg/ml
Interval 193.625 to 305.081
|
224.425 pg/ml
Interval 197.557 to 382.366
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 8 hour post bypass
|
264.061 pg/ml
Interval 161.506 to 298.064
|
243.292 pg/ml
Interval 175.307 to 312.665
|
|
The Examine and Measure Cytokines to Measure Kidney Injury
G-CSF 24 hour post bypass
|
309.690 pg/ml
Interval 161.764 to 385.424
|
199.849 pg/ml
Interval 128.946 to 286.537
|
PRIMARY outcome
Timeframe: 30 days from the start of infusionPopulation: randomized as outlined in the protocol
Serial measurements of Endothelin-1 levels were measured to determine if natriuretic peptides exert their renal protective effects by preserving renal afferent arteriole flow by antagonizing the vasoconstrictive effects of Endothelin-1.
Outcome measures
| Measure |
Nesiritide
n=14 Participants
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 Participants
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
baseline prior to infusion
|
1.778 pg/ml
Interval 1.443 to 2.149
|
1.239 pg/ml
Interval 0.991 to 2.557
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
time point 0
|
2.096 pg/ml
Interval 1.899 to 2.568
|
2.283 pg/ml
Interval 1.924 to 3.077
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
1 hour post bypass
|
1.670 pg/ml
Interval 1.334 to 2.383
|
2.068 pg/ml
Interval 1.399 to 2.665
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
2 hour post bypass
|
2.173 pg/ml
Interval 1.898 to 2.507
|
2.201 pg/ml
Interval 1.591 to 2.915
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
4 hour post bypass
|
2.395 pg/ml
Interval 2.237 to 2.988
|
3.116 pg/ml
Interval 2.157 to 4.45
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
6 hour post bypass
|
2.627 pg/ml
Interval 2.32 to 3.317
|
3.485 pg/ml
Interval 2.421 to 4.633
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
8 hour post bypass
|
2.744 pg/ml
Interval 2.454 to 3.369
|
3.143 pg/ml
Interval 2.52 to 4.079
|
|
The Examine and Measure Endothelin-1 to Measure Kidney Injury
24 hour post bypass
|
1.900 pg/ml
Interval 1.55 to 2.901
|
2.269 pg/ml
Interval 1.688 to 3.541
|
PRIMARY outcome
Timeframe: A change in urinary NGAL 2 hours after bypass was stopped and 5 minutes after the start of spontaneous circulation was resumed.Population: randomized as outlined in protocol
Urinary NGAL,a biomarker for kidney injury was measured.
Outcome measures
| Measure |
Nesiritide
n=14 Participants
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 Participants
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
The Examine and Measure Urinary NGAL to Measure Kidney Injury
|
124.566 ng/ml
Interval 29.819 to 340.163
|
33.766 ng/ml
Interval 9.825 to 425.434
|
Adverse Events
Nesiritide
Serious events: 0 serious events
Other events: 2 other events
Deaths: 0 deaths
Placebo
Serious events: 3 serious events
Other events: 1 other events
Deaths: 0 deaths
Serious adverse events
| Measure |
Nesiritide
n=14 participants at risk
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 participants at risk
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
General disorders
Syncope
|
0.00%
0/14 • June 2010 to December 2012
|
6.7%
1/15 • Number of events 1 • June 2010 to December 2012
|
|
Cardiac disorders
Atrial Fibrillation
|
0.00%
0/14 • June 2010 to December 2012
|
6.7%
1/15 • Number of events 1 • June 2010 to December 2012
|
|
Respiratory, thoracic and mediastinal disorders
Death
|
0.00%
0/14 • June 2010 to December 2012
|
6.7%
1/15 • Number of events 1 • June 2010 to December 2012
|
Other adverse events
| Measure |
Nesiritide
n=14 participants at risk
infuses at 0.01 MCG (micrograms)/KG (kilograms)/min (minute) for 48 hours
Nesiritide: infuses at 0.01MCG/KG/min for 48 hours
|
Placebo
n=15 participants at risk
infuses at 0.01MCG/KG/min for 48 hours
Placebo: infuses at 0.01MCG/KG/min for 48 hours
|
|---|---|---|
|
Surgical and medical procedures
Mediastinal exploration with evacuation of mediastinal and right clots/blood
|
7.1%
1/14 • Number of events 1 • June 2010 to December 2012
|
0.00%
0/15 • June 2010 to December 2012
|
|
Cardiac disorders
Chest pain/ dysphagia
|
7.1%
1/14 • Number of events 1 • June 2010 to December 2012
|
0.00%
0/15 • June 2010 to December 2012
|
|
Respiratory, thoracic and mediastinal disorders
Shotness of breath
|
0.00%
0/14 • June 2010 to December 2012
|
6.7%
1/15 • Number of events 1 • June 2010 to December 2012
|
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place