MedTrace Logo

SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

NCT01435759 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 1197

Last updated 2021-06-09

Study results available
· View outcomes & findings →

Summary

This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms. The purpose of this study is to help answer the following questions:

* How safe is SPD489 for the supplemental treatment of depression and what are the side effects that might be related to it?
* Can SPD489 help patients with depression who are also taking an antidepressant?
* How much SPD489 should be given to patients with depression who are also taking an antidepressant?
* How does SPD489 compare to placebo in depressed patients who are also taking an antidepressant?

Conditions

Interventions

DRUG

Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 10 mg

Antidepressant + SPD489 oral, 10 mg, once daily for 8 weeks

DRUG

Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 30 mg

Antidepressant + SPD489 oral, 30 mg, once daily for 8 weeks

DRUG

Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 50 mg

Antidepressant + SPD489 oral, 50 mg, once daily for 8 weeks

DRUG

Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 70 mg

Antidepressant + SPD489 oral, 70 mg, once daily for 8 weeks

DRUG

Antidepressant + Placebo

oral, once daily for 8 weeks

Sponsors & Collaborators

  • Shire

    lead INDUSTRY

Principal Investigators

  • Study Director · Takeda

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2014-01-17
Completion
2014-01-17

Countries

  • United States
  • Argentina
  • Australia
  • Chile
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01435759 on ClinicalTrials.gov