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The Effects of Bethanechol on Glucose Homeostasis

NCT01434901 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2018-05-08

No results posted yet for this study

Summary

Xenin-25 and glucose-dependent insulinotropic polypeptide (GIP) are hormones produced in the intestine that are released into the blood immediately after ingestion of a meal. Together, these 2 hormones increase insulin release and reduce blood glucose levels. Xenin-25 works by increasing acetylcholine release in pancreatic islets. This study will determine if a Bethanechol, a drug that is similar to acetylcholine, also increases insulin release and reduces blood glucose levels after ingestion of a mixed meal.

Conditions

Interventions

DRUG

Placebo

A placebo will be taken by mouth 1 hour before ingestion of a mixed meal.

DRUG

Bethanechol (25 mg)

25 mg of Bethanechol will be taken by mouth 1 hour before ingestion of a mixed meal

DRUG

Bethanechol (50 mg)

50 mg of Bethanechol will be taken by mouth 1 hour before ingestion of a mixed meal

DRUG

Bethanechol (100 mg)

100 mg of Bethanechol will be taken by mouth 1 hour before ingestion of a mixed meal

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Burton M Wice, PhD · Washington University School of Medicine

  • Dominic Reeds, MD · Washington University School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-08-15
Primary Completion
2014-07-07
Completion
2014-07-07

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01434901 on ClinicalTrials.gov