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Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches

NCT01406860 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2017-12-05

Study results available
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Summary

The purpose of this study is to determine if droperidol is equally as effective as metoclopramide for treatment of primary headaches in the Emergency Department.

Conditions

  • Primary Headaches (Includes Migraines, Tension, Cluster Headaches)

Interventions

DRUG

Droperidol

Droperidol 1.25 mg IV x 1, may repeat 0.625 mg if needed at 60 minutes

DRUG

Metoclopramide + diphenhydramine

Metoclopramide 20 mg IV infusion q30 minutes as needed with a maximum of 4 doses + Diphenhydramine 25 mg IV injection x 1 given with the first dose of metoclopramide IV infusion and repeated x 1 given with the third metoclopramide IV infusion.

Sponsors & Collaborators

  • University of Iowa

    lead OTHER

Principal Investigators

  • Jon Van Heukelom, MD · University of Iowa

  • Christopher Hogrefe, MD · University of Iowa

  • Brett Faine, PharmD · University of Iowa

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2012-07-31
Completion
2012-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01406860 on ClinicalTrials.gov