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Prediction of ARrhythmic Events With Positron Emission Tomography

NCT01400334 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 257

Last updated 2020-10-12

No results posted yet for this study

Summary

The hypothesis of PAREPET is that hibernating myocardium (viable myocardium with reduced resting flow) and/or viable but denervated myocardium can predict the risk of sudden death in subjects with ischemic cardiomyopathy.

Conditions

  • Ischemic Cardiomyopathy
  • Hibernating Myocardium
  • Nerve; Disorder, Sympathetic

Interventions

RADIATION

Positron Emission Tomography

Quantification of cardiac function using positron emission tomography and: a)11C-meta-hydroxyephedrine \[HED, 20 mCi (740 MBq)\] to quantify sympathetic nerve function, b) 13N-ammonia \[NH3, 20 mCi (740 MBq)\] for regional perfusion, and c) 18F-2-deoxyglucose \[FDG; 6.5 mCi (241 MBq)\] administered during a hyperinsulinemic-euglycemic clamp to assess viability.

Sponsors & Collaborators

  • State University of New York at Buffalo

    lead OTHER

Principal Investigators

  • John M Canty, MD · State University of New York at Buffalo

  • James A Fallavollita, MD · State University of New York at Buffalo

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-07-31
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01400334 on ClinicalTrials.gov