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Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides

NCT01375153 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2017-04-06

No results posted yet for this study

Summary

Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes. The pathophysiological mechanisms linking heart failure and appetite-regulation remain unknown. This study aims to examine the impact of exogenous BNP administration on subjective ratings of hunger and satiety, and on appetite-regulating hormones in a placebo-controlled cross-over study performed in ten healthy human volunteers.

Conditions

  • Healthy

Interventions

DRUG

BNP

3.0 pmol/kg/min human active BNP administered as a continuous intravenous infusion during four hours

DRUG

0.9% NaCl

0.9% NaCl administered as a continuous intravenous infusion during four hours

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Anton Luger, MD · Medical University of Vienna

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-11-30
Primary Completion
2011-03-31
Completion
2011-05-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01375153 on ClinicalTrials.gov