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Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery

NCT01297803 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2011-02-17

No results posted yet for this study

Summary

Application of antimetabolite agents such as mitomycin\_c has improved trabeculectomy results and better control of intraocular pressure complications such as corneal endothelial cell loss. However, Mitomycin\_c can be applied remain a concern before or after sclera flap dissection. Mitomycin\_c application after sclera flap dissection probably increases corneal endothelial cell loss. This study compares Mitomycin\_c application two methods: before and after sclera flap dissection with regard to success rate and complication. patients on base of Mitomycin\_c application time (1-2-3) minutes will be match randomise in to two groups( before and after sclera flap dissection) corneal. Endothelial cell density, polymorphism, polymegathism and intraocular pressure before and one month, three months, six months after surgery will measured.

Conditions

  • Glaucoma Patients Scheduled for Trabeculectomy

Interventions

DRUG

Mitomycin_c

0.02%.1,2,3,minutes match randomized in to two groups(before \&after scleral flap dissection

DRUG

Mitomycin_c

0.02%.1,2,3,minutes match randomized in to two groups(before \&after scleral flap dissection

Sponsors & Collaborators

  • Shahid Beheshti University of Medical Sciences

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-11-30
Primary Completion
2011-06-30
Completion
2011-12-31

Countries

  • Iran

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01297803 on ClinicalTrials.gov