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Imaging of Cognition, Learning, and Memory in Aging

NCT01297114 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 294

Last updated 2017-11-01

No results posted yet for this study

Summary

This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging. Implicit memory tasks may be distinguished from explicit memory tests in that explicit memory characterizes the directed or intentional recollection of previously learned information or events. In contrast, implicit (or nonconscious) memory is expressed in the facilitation of performance on some task or judgment on a stimulus owing to a prior presentation of that stimulus, without any necessary conscious awareness of the prior presentation. The investigators propose to use functional Magnetic resonance Imaging (fMRI) to measure brain activity during the performance of carefully designed explicit memory tasks. Comparison of brain activity during the different test conditions will provide information about the brain areas that are involved in mediating specific aspects of performance. Both older and younger individuals will be tested in order to understand age related changes in the brain activity. In order to examine the interactions between participants' differential levels of amyloid burden and their performance on cognitive tasks and fMRI neural activation, the investigators also propose PET imaging of older participants.

Conditions

Interventions

DRUG

Florbetaben

This is a purely observational study. Results of the Florbetaben PET scan will be correlated with other observations.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Yaakov Stern

    lead OTHER

Principal Investigators

  • Yaakov Stern, PhD · Columbia University

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2017-10-01
Completion
2017-10-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01297114 on ClinicalTrials.gov