Kidney Transplant Failure

Summary

Primary Hypotheses:

1. Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have more deaths than patients who discontinue these drugs
2. Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have more hospitalizations for sepsis than patients who discontinue these drugs
3. Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have fewer rejection events than patients who discontinue these drugs

Secondary Hypotheses:

1. Patients who undergo elective nephrectomy (to remove the failed kidney transplant) will have fewer deaths than those who retain the failed kidney transplant
2. Patients who undergo elective nephrectomy (to remove the failed kidney transplant) will have fewer hospitalizations for sepsis than those who retain the failed kidney transplant
3. Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have lower levels of allosensitization (anti-HLA antibodies) than those who discontinue these drugs
4. Patients who undergo elective nephrectomy will have higher levels of allosensitization (anti-HLA antibodies) than patients who retain the failed kidney transplant

Conditions

• Acute Graft Rejection
• Renal Failure Chronic Requiring Dialysis

Sponsors & Collaborators

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• St. Paul's Hospital, Canada

  collaborator OTHER

• Vancouver General Hospital

  collaborator OTHER

• Kingston Health Sciences Centre

  collaborator OTHER

• University of Saskatchewan

  collaborator OTHER

• University of Calgary

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• Unity Health Toronto

  collaborator OTHER

• St. Joseph's Healthcare Hamilton

  collaborator OTHER

• London Health Sciences Centre

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• Maisonneuve-Rosemont Hospital

  collaborator OTHER

• Centre hospitalier de l'Université de Montréal (CHUM)

  collaborator OTHER

• CHU de Quebec-Universite Laval

  collaborator OTHER

• University of Alberta

  collaborator OTHER

• Ottawa Hospital Research Institute

  lead OTHER

Principal Investigators

• Greg Knoll, MD · U of Ottawa, The Ottawa Hospital, OHRI

• John Gill, MD · UBC, St Paul's Hospital Vancouver, BC

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-08-31

Primary Completion

2016-10-31

Completion

2017-07-31

Countries

• Canada

Study Locations