Nonmyeloablative Allogeneic Transplant
NCT01272817 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2022-11-23
Summary
Allogeneic transplant from a matched sibling for the treatment of a variety of illnesses including bone marrow failure states, leukemias, myelodysplastic or myeloproliferative syndromes, lymphoma, or myeloma using a nonmyeloablative preparative regimen.
Conditions
- Aplastic Anemia
- Paroxysmal Nocturnal Hemoglobinuria
- Acute Myelogenous Leukemia
- Acute Lymphocytic Leukemia
- Myelodysplastic Syndrome
- Chronic Myelogenous Leukemia
- Chronic Lymphocytic Leukemia
- Hodgkin's Lymphoma
- Non-Hodgkin's Lymphoma
- Mantle Cell Lymphoma
- Multiple Myeloma
- Waldenstrom Macroglobulinemia
- Breast Cancer
- Renal Cell Carcinoma
- Melanoma
- Sarcoma
- Ovarian Cancer
- Thymoma
Interventions
- PROCEDURE
-
Nonmyeloablative Allogeneic Transplant
Cladribine 0.14 mg/kg/day for five days, melphalan 100 mg/m2 on one day
- PROCEDURE
-
Nonmyeloablative Allogeneic Transplant
Total lymphoid irradiation 100cGy/day times 10 days (Monday through Friday)
Sponsors & Collaborators
-
Scripps Health
lead OTHER
Principal Investigators
-
Jeffrey W. Andrey, M.D. · Scripps Health
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 72 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2001-10-31
- Primary Completion
- 2015-10-31
- Completion
- 2015-10-31
Countries
- United States
Study Locations
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