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Acoustic Radiation Force Impulse (ARFI)Technology in Prediction of Liver Fibrosis

NCT01268865 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2011-06-03

No results posted yet for this study

Summary

Background: In patients with chronic liver diseases, liver fibrosis staging is crucial for hazard evaluation of future disease complication development and thus for the optimal decision making on treatment selections.In the era of antiviral and antifibrotic treatments, clinical and research demands are also increasing for non-invasive surveillance of liver fibrosis to evaluate the progression or regression. However, local baseline data on liver stiffness measurement (LSM) using ARFI technique is still lacking in Taiwan, where viral hepatitides are highly endemic. Aim: Using the ARFI elastosonography, we are dedicated to the aims to recruit patients based on strict but appropriate criteria, to complete the correlation and validity studies between ARFI quantification and the referenced METAVIR fibrosis scoring and to conduct subsequent innovative studies on liver diseases. Materials and Methods: We plan to perform the ARFI quantification for each HBV or HCV-infected patient immediately followed by priorly scheduled conventional liver biopsy for METAVIR scoring during the same session of examination. Statistics: The first year's study using ARFI will focus on the correlation testings and validity studies using receiver operating characteristics.

Conditions

  • Liver Fibrosis

Sponsors & Collaborators

  • China Medical University Hospital

    lead OTHER

Principal Investigators

  • Sheng-Hung Chen, MD · Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital

  • Cheng-Yuan Peng, MD, PhD · Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-12-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01268865 on ClinicalTrials.gov