A Study of ABT-806 in Subjects With Advanced Solid Tumor Types
NCT01255657 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 49
Last updated 2017-11-21
Summary
This is an open-label study designed to determine the recommended Phase 2 dose (RPTD) and evaluate the safety and pharmacokinetics of ABT-806 in subjects with advanced solid tumors.
Conditions
Interventions
- DRUG
-
ABT-806
ABT-806 will be administered by intravenous infusion.
Sponsors & Collaborators
-
AbbVie (prior sponsor, Abbott)
lead INDUSTRY
Principal Investigators
-
Kyle D. Holen, MD · AbbVie
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 99 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2010-11-30
- Primary Completion
- 2012-11-30
- Completion
- 2012-11-30
Countries
- United States
Study Locations
More Related Trials
-
Abivertinib Maleate Versus Geifitinib in Patients With Advanced Non-small Cell Lung Cancer With Sensitive EGFR Mutation
NCT03856697 ·Status: UNKNOWN ·Phase: PHASE3
-
An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)
NCT01853826 ·Status: COMPLETED ·Phase: PHASE3
-
D-0316 in Patients With EGFR Positive Non Small Cell Lung Cancer
NCT03861156 ·Status: COMPLETED ·Phase: PHASE2
-
GIOTRIF in First Line Therapy of Advanced NSCLC With EGFR-mutations
NCT02047903 ·Status: COMPLETED
-
A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
NCT06685718 ·Status: TERMINATED ·Phase: PHASE1
-
Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR Mutation
NCT01953913 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies
NCT02108964 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
ABX-EGF as Second Line Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC)
NCT00101920 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study of Afatinib as Third- or Further-line Treatment for Patients With Stage IV Bronchial Adenocarcinoma, Harboring Wild-type EGFR, Expressing the Neurotensin - Neurotensin Receptor Complex
NCT02876081 ·Status: WITHDRAWN ·Phase: PHASE2
-
Apatinib in the Treatment of Patients With EGFR T790M-Negative NSCLC
NCT03389256 ·Status: UNKNOWN ·Phase: PHASE2
-
Local Therapies for Oligometastatic Non-Small Cell Lung Cancer Harboring Sensitizing EGFR Mutations
NCT02450591 ·Status: COMPLETED ·Phase: NA
-
A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC
NCT06010329 ·Status: RECRUITING ·Phase: PHASE2
-
Afatinib Combined With Chemotherapy as Conversion Therapy in Unresectable EGFR Sensitive Mutation-positive Stage III NSCLC
NCT06709859 ·Status: RECRUITING ·Phase: PHASE2
-
The Study of Apatinib Plus CIK as the Third Line Therapy for Advanced Lung Adenocarcinoma Patients With Wild-Type EGFR
NCT02493582 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Afatinib in EGFR+NSCLC (Recurrent or Stage IV) - Patients With Poor Performance Status (ECOG 2 or 3)
NCT02695290 ·Status: TERMINATED ·Phase: PHASE4
-
Adjuvant Afatinib in Stage I-III NSCLC With EGFR Mutation
NCT01746251 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers
NCT03144856 ·Status: UNKNOWN ·Phase: PHASE2
-
EGFR-TKIs Combine Chemotherapy as First-line Therapy for Patients With Advanced EGFR Mutation-positive NSCLC
NCT02886195 ·Status: UNKNOWN ·Phase: PHASE3
-
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
NCT05099172 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
First-Line EGFR-1 Tyrosine Kinase Inhibition in Patients With NSCLC With Mutant EGFR Gene
NCT00339586 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of EGFR TKI in Patients With Advanced NSCLC Harbouring EGFR Mutations
NCT06062823 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Afatinib Therapy for Potentially Resectable Stage III EGFR Mutation-Positive Lung Adenocarcinoma
NCT04201756 ·Status: COMPLETED ·Phase: PHASE2
-
Apatinib Plus Docetaxel as 2nd Line Treatment in Patients With Advanced Lung Adenocarcinoma Harboring Wild-type EGFR
NCT02691871 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases
NCT04603807 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Study of Safety and Efficacy of EGFR-TKI EGF816 in Combination With cMET Inhibitor INC280 in Adult Patients With EGFR Mutated Non Small Cell Lung Cancer.
NCT02335944 ·Status: TERMINATED ·Phase: PHASE1/PHASE2