Genetics in Non-response to Anti-VEGF Treatment in Exudative AMD
NCT01213667 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 110
Last updated 2016-10-26
Summary
To assess genetic features and intraocular cytokine profiles of non-responders to anti-VEGF treatment of exudative age-related macular degeneration. Also to assess necessity and frequency of pro re nate medical re-treatment.
Conditions
- Macular Degeneration
Interventions
- DRUG
-
upload (three monthly injections), re-treatment as needed
Sponsors & Collaborators
-
University of Cologne
lead OTHER
Principal Investigators
-
Philipp S Muether, MD · Center of Ophthalmology, University of Cologne
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2010-01-31
- Primary Completion
- 2017-12-31
- Completion
- 2017-12-31
Countries
- Germany
Study Locations
More Related Trials
-
Seven-year Outcomes Following Intensive Anti-VEGF Therapy in Wet AMD
NCT05678517 ·Status: COMPLETED
-
Anti-VEGF Therapy for Subfoveal Hemorrhage in Patients With Neovascular Age-Related Macular Degeneration
NCT03699618 ·Status: TERMINATED
-
Genetic Study of Age-Related Macular Degeneration
NCT00357578 ·Status: COMPLETED
-
Safety and Tolerability of Intravenous LFG316 in Wet Age-related Macular Degeneration (AMD).
NCT01624636 ·Status: TERMINATED ·Phase: PHASE2
-
Genetic Load and Phenotype in Aggressive AMD
NCT01650948 ·Status: COMPLETED
-
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
NCT06635148 ·Status: RECRUITING ·Phase: PHASE2
-
Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
NCT00509795 ·Status: COMPLETED ·Phase: PHASE3
-
A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration
NCT01678872 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases
NCT03128463 ·Status: UNKNOWN
-
Comparison of Pharmacokinetics of and Effect on Systemic VEGF Levels in Age Related Macular Degeneration Patients
NCT02296567 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Characteristics of Patients With Neovascular Age-related Macular Degeneration Enrolled in the Brolucizumab Patient Support Services Program
NCT05066685 ·Status: COMPLETED
-
Effectiveness of Anti-VEGF Treatments in Wet AMD in Active Smokers
NCT04685369 ·Status: COMPLETED
-
Evaluation of AGN-150998 in Exudative Age-related Macular Degeneration (AMD)
NCT01397409 ·Status: COMPLETED ·Phase: PHASE2
-
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)
NCT00637377 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD)
NCT01024998 ·Status: COMPLETED ·Phase: PHASE1
-
Cohort Study of the Clinical Course of Macular Diseases in Japanese
NCT02081339 ·Status: UNKNOWN
-
Safety and Tolerability Study of Intravitreal VEGF-Trap Administration in Patients With Neovascular AMD
NCT00320775 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Ranging Study of Pazopanib to Treat Neovascular Age-Related Macular Degeneration
NCT01134055 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT02399072 ·Status: TERMINATED
-
Effectiveness of Brolucizumab in Pre-treated Patients With nAMD in the Real-world Setting
NCT05266495 ·Status: TERMINATED
-
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT02479386 ·Status: TERMINATED
-
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)
NCT02762188 ·Status: COMPLETED ·Phase: NA
-
A Study of EXG102-031 in Patients With wAMD (Everest)
NCT05903794 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO6867461 Administered in Single- and Multiple-Ascending Doses in Patients With Wet Age-Related Macular Degeneration
NCT01941082 ·Status: COMPLETED ·Phase: PHASE1
-
Study of MP0112 Intravitreal Injection in Patients With Wet Age Related Macular Degeneration
NCT01086761 ·Status: TERMINATED ·Phase: PHASE1