Growth Observational Study

Summary

This study was a multicenter, prospective cohort study to define postnatal longitudinal growth for very low birth weight (VLBW) infants. The objectives were: 1) to develop postnatal growth curves for VLBW preterm infants that would permit an assessment of growth velocity; 2) to relate growth velocity and nutritional practices (duration of parenteral nutrition, age at first enteral feeding, and age at full enteral feeding); 3) to compare growth velocity in infants who are small-for-gestational age (SGA) with infants who are appropriate-for-gestational age (AGA); and 4) to relate growth velocity to several common, major morbidities, including chronic lung disease (CLD), nosocomial infection (or late-onset infection) and necrotizing enterocolitis (NEC). These growth data may be useful in identifying preterm infants who are growing slowly despite current nutritional support and in designing and performing clinical trials of nutritional interventions.

Conditions

• Infant, Newborn
• Infant, Low Birth Weight
• Infant, Small for Gestational Age
• Infant, Premature

Sponsors & Collaborators

• National Center for Research Resources (NCRR)

  collaborator NIH

• NICHD Neonatal Research Network

  lead NETWORK

Principal Investigators

• Richard A. Ehrenkranz, MD · Yale University

• Avroy A. Fanaroff, MD · Case Wester Reserve University

• Edward F. Donovan, MD · Children's Hospital Medical Center, Cincinnati

• Barbara J. Stoll, MD · Emory University

• Joel Verter, PhD · George Washington University

• James A. Lemons, MD · Indiana University

• Charles R. Bauer, MD · University of Miami

• Lu-Ann Papile, MD · University of New Mexico

• David K. Stevenson, MD · Stanford University

• Sheldon B. Korones, MD · University of Tennessee at Memphis

• Jon E. Tyson, MD · University of Texas

• Seetha Shankaran, MD · Wayne State University

• William Oh, MD · Brown University, Womens and Infants Hospital

Eligibility

Max Age

24 Hours

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1994-08-31

Primary Completion

1995-08-31

Completion

1995-08-31

Countries

• United States

Study Locations