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Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)

NCT01202656 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 129

Last updated 2014-12-02

Study results available
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Summary

This a trial designed to test whether granulocyte colony stimulating factor (G-CSF, Neupogen) can increase the rate of embryo implantation following IVF and embryo transfer. Preliminary data at the Center for Human Reproduction(CHR) and elsewhere suggest that intrauterine infusion of G-CSF can improve endometrial development and can increase implantation rates of embryos.

Conditions

  • Infertility, Female

Interventions

DRUG

G-CSF

One infusion of G-CSF 300 units administered by intrauterine infusion

DRUG

Saline

intrauterine saline infusion 1 cc

Sponsors & Collaborators

  • Foundation for Reproductive Medicine

    collaborator OTHER

  • Center for Human Reproduction

    lead OTHER

Principal Investigators

  • David H Barad, MD, MS · Center for Human Reproduction

  • Norbert Gleicher, MD · Center for Human Reproduction

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2012-12-31
Completion
2013-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01202656 on ClinicalTrials.gov