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Functional Imaging of the Therapeutic Effect of Pregabalin in Treatment for Neuropathic Pain

NCT01180608 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2010-08-12

No results posted yet for this study

Summary

Functional Imaging of the therapeutic effect of Pregabalin in treatment for neuropathic pain in patients with Diabetic Polyneuropathy using proton Magnetic Resonance Spectroscopy (MRS):

The aim of our study is to investigate the effect of Pregabalin as a treatment for neuropathic pain in a homogeneous study population, using proton MRS (1H MRS) focusing on four regions of interest (bilateral thalami, rostral anterior cingulated cortex (rACC) and dominant dorsolateral prefrontal cortex (DLPC).

Conditions

  • Diabetic Neuropathies
  • Pain

Interventions

OTHER

MR Spectroscopy

During each MR Spectroscopy session, we will measure at regions of interest (rACC, both thalami, dominant DLPC) the levels of the following biochemical substances: * gamma-aminobutyric acid (GABA) * glutamate (Glu) * glutamine (Gln) * N-acetylaspartate (NAA) * Choline-containing compounds (Cho) * Creatine plus phophocreatine (total creatine: Cr) * Myo-inositiol (Ins) * Choline (Cho) * Glucose (Glc) * Lactate (Lac)

Sponsors & Collaborators

  • Moens Maarten

    collaborator UNKNOWN

  • Universitair Ziekenhuis Brussel

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2011-09-30
Completion
2012-09-30

Countries

  • Belgium

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01180608 on ClinicalTrials.gov