Early Detection of Cancers in Low Resource Countries

Summary

The purpose of this study is to implement a community-based combined program for early detection of breast, cervical, ovarian and endometrial cancer in low-resource countries delivered through a free standing or a mobile Well Woman Clinic. The goals of this program are to downstage cancers and improve mortality rates using low-cost early detection methods. These programs will be implemented in regions where early cancer detection strategies are not in place and cancers present at advanced stages with resultant high mortality. Currently, there are three target project sites: Cambodia (June 2011), India (June 2011), and Brazil (March 2011). Memorandums of Understanding have been secured with local health organizations in each region to establish clinic operations. Each clinic would serve an approximate target population of 100,000 amongst whom about 12,000 eligible women (4-5,000 annually) will be invited to be screened for breast and cervical cancer over a three-year time span.

Conditions

• Breast Neoplasms
• Uterine Cervical Neoplasms
• Ovarian Neoplasms
• Endometrial Neoplasms

Interventions

PROCEDURE

Breast Cancer Screening and Diagnosis

Clinical Breast Examination and Sonography followed by Fine needle aspiration biopsy (FNAB) of screen positive cases.

PROCEDURE

Cervical Cancer Screening and Diagnosis

Visual Inspection with Acetic acid, PAP smear or Human Papilloma Virus DNA testing followed by Cryotherapy of screen positive cases.

PROCEDURE

Ovarian Cancer Screening and Diagnosis

Transvaginal sonogram and clinical evaluation in post menopausal women with symptoms suggestive of ovarian cancer.

PROCEDURE

Endometrial Cancer Screening and Diagnosis

Transvaginal sonographic assessment of the endometrial stripe in post menopausal women with abnormal bleeding.

Sponsors & Collaborators

• Woman's Cancer Foundation

  lead OTHER

Principal Investigators

• Weiwei Yang, MD · M.D. Anderson Cancer Center, University of Texas

• Diljeet K Singh, MD · Northwestern University Feinberg School of Medicine

• Adhemar Longatto Filho, MD · University of Sao Paolo

Eligibility

Min Age

30 Years

Max Age

64 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2011-03-31

Primary Completion

2014-03-31

Completion

2014-03-31

Countries

• Brazil
• Cambodia
• India

Study Locations