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Longitudinal Study of Patients Following Long Bone Fracture

NCT01170572 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 33

Last updated 2012-11-07

No results posted yet for this study

Summary

Studies in chickens show that blood levels of a particular form of vitamin D (called 24,25-dihydroxvitamin D) increase after bone fracture. Laboratory studies show that this form of vitamin D helps the bone healing process in chickens. The investigators want to find out whether blood levels of this form of vitamin D increase after bone fracture in humans. Previous research studies have not addressed this question. The results of this research could eventually lead to the development of new treatments to help bone healing after fracture.

Patients will be asked to take part in this study if they are aged 16 years or older and come to the Royal London Hospital with a broken bone in the arm or leg or collar bone (clavicle). They will be asked to give a 20ml (about 4 teaspoons) blood sample on three occasions: at the start of the study, at 5-14 days after the fracture; and at 4-10 weeks after the fracture. The rest of their normal care would not be affected. Follow-up blood samples will be timed to coincide with routine clinic visits which are scheduled as part of normal clinical care. Patients' vitamin D level will be measured as part of the study, and those who have a low vitamin D level will be informed about this, and advised about appropriate vitamin D supplementation. The investigators will let the patient or their GP know if any blood tests are abnormal

Conditions

  • Vitamin D
  • Long Bone Fracture

Interventions

OTHER

No intervention

No intervention

Sponsors & Collaborators

  • London Deanery

    collaborator UNKNOWN

  • Barts & The London NHS Trust

    lead OTHER

Principal Investigators

  • Adrian Martineau, MRCP · Queen Mary University of London

  • Tim Harris, BM BS · Barts and the London NHS Trust

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01170572 on ClinicalTrials.gov